Cost-effectiveness of interferon ? or peginterferon ?, with ribavirin for histologically mild chronic hepatitis C


Grieve, Richard, Roberts, Jennifer, Wright, Mark, Sweeting, Michael, DeAngelis, Daniela, Rosenberg, William, Bassendine, Margaret, Main, Janice and Thomas, Howard (2006) Cost-effectiveness of interferon ? or peginterferon ?, with ribavirin for histologically mild chronic hepatitis C. Gut, 55, (9), 1332-1338. (doi:10.1136/gut.2005.064774).

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Original Publication URL: http://dx.doi.org/10.1136/gut.2005.064774

Description/Abstract


Background: For patients with mild chronic hepatitis C the cost-effectiveness of antiviral therapy is unknown.

Aims: To assess whether anti-viral therapy (either interferon ? or peginterferon ? combined with ribavirin) is cost-effective at a mild stage compared to waiting and only treating those cases whoprogress to moderate disease.

Patients: Cases with mild chronic hepatitis C.

Methods: A cost-effectiveness model estimates long-term costs and outcomes for patients with mild chronic hepatitis C. The model uses effectiveness and cost data from the UK mild hepatitis C RCT, combined with estimates of disease progression and cost from observational studies.

Results: Antiviral treatment at a mild rather than a moderate stage improved outcomes measured by Quality Adjusted Life Years (QALYs) gained. The mean cost per QALY gained from
antiviral treatment with interferon ??2b and ribavirin, compared to no treatment at a mild stage, was £4,535 ($7,108) for patients with genotype non-1 and £25,188 ($39,480) for patients with
genotype 1. Providing peginterferon ??2b and ribavirin at a mild rather than a moderate stage was also associated with a gain in QALYs; the costs per QALY gained were £7,821 ($12,259)
for patients with genotype non-1 and £28,409 ($44,528) for patients with genotype 1.

Conclusions: For patients with chronic hepatitis C, it is generally more cost-effective to provide antiviral treatment at a mild rather than a moderate disease stage. For older patients (aged 65 or over) with genotype 1, antiviral treatment at a mild stage is not cost-effective.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1136/gut.2005.064774
ISSNs: 0017-5749 (print)
Related URLs:
Keywords: cost-effectiveness model, cost analysis, antiviral therapy
Subjects: Q Science > QR Microbiology > QR355 Virology
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions : University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
ePrint ID: 27074
Accepted Date and Publication Date:
Status
2006Published
Date Deposited: 25 Apr 2006
Last Modified: 31 Mar 2016 11:50
URI: http://eprints.soton.ac.uk/id/eprint/27074

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