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Mechanisms of airway epithelial damage: epithelial-mesenchymal interactions in the pathogenesis of asthma

Mechanisms of airway epithelial damage: epithelial-mesenchymal interactions in the pathogenesis of asthma
Mechanisms of airway epithelial damage: epithelial-mesenchymal interactions in the pathogenesis of asthma
The aims of this article are to understand the shortfalls in thinking of asthma purely as an atopic disorder, to gain insight into the epithelial abnormalities of asthma and how these interface with the environment, and to view asthma as a disease of airway wall restructuring that engages activation of the epithelial mesenchymal trophic unit (EMTU). Furthermore, based on these developments, possible novel therapeutic targets for chronic asthma are identified.
0904-1850
24s-29s
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Davies, D.E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Puddicombe, S.
a7709d74-aa6f-458b-aaf2-55430ef9db96
Richter, A.
080ff20b-2ec5-4204-a809-2d1c63e4be1f
Lackie, P.
4afbbe1a-22a6-4ceb-8cad-f3696dc43a7a
Lordan, J.
c7a31d0c-ffa9-4073-a5e5-4ca166e9df14
Howarth, P.
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Davies, D.E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Puddicombe, S.
a7709d74-aa6f-458b-aaf2-55430ef9db96
Richter, A.
080ff20b-2ec5-4204-a809-2d1c63e4be1f
Lackie, P.
4afbbe1a-22a6-4ceb-8cad-f3696dc43a7a
Lordan, J.
c7a31d0c-ffa9-4073-a5e5-4ca166e9df14
Howarth, P.
ff19c8c4-86b0-4a88-8f76-b3d87f142a21

Holgate, S.T., Davies, D.E., Puddicombe, S., Richter, A., Lackie, P., Lordan, J. and Howarth, P. (2003) Mechanisms of airway epithelial damage: epithelial-mesenchymal interactions in the pathogenesis of asthma. European Respiratory Journal Supplement, 44, 24s-29s. (doi:10.1183/09031936.03.00000803).

Record type: Article

Abstract

The aims of this article are to understand the shortfalls in thinking of asthma purely as an atopic disorder, to gain insight into the epithelial abnormalities of asthma and how these interface with the environment, and to view asthma as a disease of airway wall restructuring that engages activation of the epithelial mesenchymal trophic unit (EMTU). Furthermore, based on these developments, possible novel therapeutic targets for chronic asthma are identified.

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Published date: 2003

Identifiers

Local EPrints ID: 27114
URI: http://eprints.soton.ac.uk/id/eprint/27114
ISSN: 0904-1850
PURE UUID: 764f3113-b850-478d-a724-8704b5a0be5e
ORCID for D.E. Davies: ORCID iD orcid.org/0000-0002-5117-2991
ORCID for P. Lackie: ORCID iD orcid.org/0000-0001-7138-3764

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 16 Mar 2024 02:45

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Contributors

Author: S.T. Holgate
Author: D.E. Davies ORCID iD
Author: S. Puddicombe
Author: A. Richter
Author: P. Lackie ORCID iD
Author: J. Lordan
Author: P. Howarth

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