MHC class I receptors on natural killer cells: on with the old and in with the new
MHC class I receptors on natural killer cells: on with the old and in with the new
The functions of natural killer (NK) cells are controlled by an abundance of activating and inhibitory receptors. Many of these interact with MHC class I molecules. The MHC system also interacts with cytotoxic T-lymphocytes and has been shown to comprise a rapidly evolving family of molecules. This challenges the functional relationship of NK cell receptors with their ligands. Although individual receptors have become subject to species-specific expansions over evolutionary time, the main themes of the NK cell interaction with MHC class I have been preserved. This review details the interaction of NK cell receptors with MHC class I and discusses their unexpectedly rapid evolution.
C-type lectin-like receptors, evolution, killer cell Ig-like receptor, MHC class I, natural killer cells
127-140
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Brooks, Collin R.
a9ae35ca-98a6-4e01-8336-859c98424b11
2003
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Brooks, Collin R.
a9ae35ca-98a6-4e01-8336-859c98424b11
Khakoo, Salim I. and Brooks, Collin R.
(2003)
MHC class I receptors on natural killer cells: on with the old and in with the new.
Clinical Science, 105 (2), .
(doi:10.1042/CS20030095).
Abstract
The functions of natural killer (NK) cells are controlled by an abundance of activating and inhibitory receptors. Many of these interact with MHC class I molecules. The MHC system also interacts with cytotoxic T-lymphocytes and has been shown to comprise a rapidly evolving family of molecules. This challenges the functional relationship of NK cell receptors with their ligands. Although individual receptors have become subject to species-specific expansions over evolutionary time, the main themes of the NK cell interaction with MHC class I have been preserved. This review details the interaction of NK cell receptors with MHC class I and discusses their unexpectedly rapid evolution.
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Published date: 2003
Keywords:
C-type lectin-like receptors, evolution, killer cell Ig-like receptor, MHC class I, natural killer cells
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Local EPrints ID: 27202
URI: http://eprints.soton.ac.uk/id/eprint/27202
ISSN: 0143-5221
PURE UUID: a34df9d0-7f9f-4f75-a15e-909bae0b719e
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Date deposited: 28 Apr 2006
Last modified: 16 Mar 2024 03:25
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Author:
Collin R. Brooks
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