Prediction of Polymorphic Form from Experimental and Theoretical Data

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Description/Abstract

Some substances have the ability to exist in more than one crystal form which is called polymorphism. This phenomenon is commonly observed in the pharmaceutical industry as a result of its serious problems. Although the polymorphs of one substance are chemically identical, their properties might be different. This can affect how well a drug performs and also affect its stability in air, light or when compressed into a tablet. One of the major concerns in the industry is to find the right conditions that lead to a specific polymorph and they are currently unknown. Since the change in molecular level properties in a solution leads to different polymorphic forms, determining the pivotal properties that cause crystallisation of one polymorph over another is a key for understanding the causes of polymorphism and that the main focus of this research.