A review of the use of olopatadine in allergic conjunctivitis
A review of the use of olopatadine in allergic conjunctivitis
Ocular allergies are very common and range in intensity from mild, self-resolving, acute conditions to serious, chronic disease that can severely affect vision. The vast majority of sufferers experience relatively mild symptoms, which are often seasonal in nature. Treatments should be simple, comfortable and very safe. They should be able to respond to an ongoing attack but also provide long-term relief from symptoms. Mast cell degranulation is central to all forms of ocular allergic disease and so treatment has concentrated on preventing this process or antagonizing the effects of the primary mediator, histamine. Olopatadine is a relatively new selective H1 antagonist that has mast cell stabilizing properties and has been shown to affect release of TNF ? and various cytokines from conjunctival epithelial cells. This paper reviews the local ocular use of olopatadine and discusses the place of the drug in the treatment of allergic eye disease.
allergic conjunctivitis, antihistamines, mast cell stabilizers, ocular allergy, olopatadine
171-179
McGill, James I.
1a4b2df8-00c4-4923-a13f-cb7340a51749
2004
McGill, James I.
1a4b2df8-00c4-4923-a13f-cb7340a51749
McGill, James I.
(2004)
A review of the use of olopatadine in allergic conjunctivitis.
International Ophthalmology, 25 (3), .
(doi:10.1007/s10792-004-1818-x).
Abstract
Ocular allergies are very common and range in intensity from mild, self-resolving, acute conditions to serious, chronic disease that can severely affect vision. The vast majority of sufferers experience relatively mild symptoms, which are often seasonal in nature. Treatments should be simple, comfortable and very safe. They should be able to respond to an ongoing attack but also provide long-term relief from symptoms. Mast cell degranulation is central to all forms of ocular allergic disease and so treatment has concentrated on preventing this process or antagonizing the effects of the primary mediator, histamine. Olopatadine is a relatively new selective H1 antagonist that has mast cell stabilizing properties and has been shown to affect release of TNF ? and various cytokines from conjunctival epithelial cells. This paper reviews the local ocular use of olopatadine and discusses the place of the drug in the treatment of allergic eye disease.
This record has no associated files available for download.
More information
Published date: 2004
Keywords:
allergic conjunctivitis, antihistamines, mast cell stabilizers, ocular allergy, olopatadine
Identifiers
Local EPrints ID: 27268
URI: http://eprints.soton.ac.uk/id/eprint/27268
ISSN: 0165-5701
PURE UUID: 8bb6e215-c15c-40bb-8ff7-6a5f8f4a82b2
Catalogue record
Date deposited: 25 Apr 2006
Last modified: 15 Mar 2024 07:17
Export record
Altmetrics
Contributors
Author:
James I. McGill
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics