[Genetic factors involved in asthma and atopy. Studies in British families]


Thomas, N.S., Wilkinson, J., Lio, P., Doull, I., Morton, N.E. and Holgate, S.T. (2000) [Genetic factors involved in asthma and atopy. Studies in British families]. Revue des Maladies Respiratoires, 17, (1 Pt 2), 177-182.

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Description/Abstract

Both asthma and atopy run families indicating a strong genetic component. To investigate possible candidate gene regions, we have recruited 131 families without reference to atopy and asthma (random sample) and 60 extended families with two or more members affected by asthma (multiplex sample). Using both candidate and genome screen approaches, we have been able to provide evidence supporting the presence of candidate genes on chromosome 11q (E237G) and 12q but we have been unable to confirm reports of linkage and association for asthma on 5q. Our experience to date suggests that larger numbers of families are needed to increase the confidence of gene localisation and there is a need to improve the phenotypic description of asthma. Finally, it is essential that claims for linkage or association are confirmed in different populations using the same markers.

Item Type: Article
Related URLs:
Subjects: H Social Sciences > HQ The family. Marriage. Woman
R Medicine > R Medicine (General)
Q Science > QH Natural history > QH426 Genetics
Divisions: University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
University Structure - Pre August 2011 > School of Medicine > Human Genetics
ePrint ID: 27449
Date Deposited: 15 Jun 2006
Last Modified: 27 Mar 2014 18:16
Contact Email Address: nst1@soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/27449

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