Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
Van Eerdewegh, Paul, Little, Randall D., Dupuis, Josée, Del Mastro, Richard G., Falls, Kathy, Simon, Jason, Torrey, Dana, Pandit, Sunil, McKenny, Joyce, Braunschweiger, Karen, Walsh, Alison, Liu, Ziying, Hayward, Brooke, Folz, Colleen, Manning, Susan P., Bawa, Alicia, Saracino, Lisa, Thackston, Michelle, Benchekroun, Youssef, Capparell, Neva, Wang, Mei, Adair, Ron, Feng, Yun, Dubois, JoAnn, FitzGerald, Michael G., Huang, Hui, Gibson, René, Allen, Kristina M., Pedan, Alex, Danzig, Melvyn R., Umland, Shelby P., Egan, Robert W., Cuss, Francis M., Rorke, Steuart, Clough, Joanne B., Holloway, John W., Holgate, Stephen T. and Keith, Tim P. (2002) Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature, 418, (6896), 426-430. (doi:10.1038/nature00878).
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Description/Abstract
Asthma is a common respiratory disorder characterized by recurrent episodes of coughing, wheezing and breathlessness. Although environmental factors such as allergen exposure are risk factors in the development of asthma, both twin and family studies point to a strong genetic component. To date, linkage studies have identified more than a dozen genomic regions linked to asthma. In this study, we performed a genome-wide scan on 460 Caucasian families and identified a locus on chromosome 20p13 that was linked to asthma (log10 of the likelihood ratio (LOD), 2.94) and bronchial hyperresponsiveness (LOD, 3.93). A survey of 135 polymorphisms in 23 genes identified the ADAM33 gene as being significantly associated with asthma using case-control, transmission disequilibrium and haplotype analyses (P = 0.04−0.000003). ADAM proteins are membrane-anchored metalloproteases with diverse functions, which include the shedding of cell-surface proteins such as cytokines and cytokine receptors. The identification and characterization of ADAM33, a putative asthma susceptibility gene identified by positional cloning in an outbred population, should provide insights into the pathogenesis and natural history of this common disease.
| Item Type: | Article |
|---|---|
| Additional Information: | Letters to Nature |
| ISSNs: | 0028-0836 (print) |
| Related URLs: | |
| Subjects: | R Medicine > RB Pathology Q Science > QH Natural history > QH426 Genetics |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair University Structure - Pre August 2011 > School of Medicine > Human Genetics |
| Item ID: | 27456 |
| Date Deposited: | 28 Apr 2006 |
| Last Modified: | 25 Apr 2013 12:30 |
| Contributors: | Van Eerdewegh, Paul (Author) Little, Randall D. (Author) Dupuis, Josée (Author) Del Mastro, Richard G. (Author) Falls, Kathy (Author) Simon, Jason (Author) Torrey, Dana (Author) Pandit, Sunil (Author) McKenny, Joyce (Author) Braunschweiger, Karen (Author) Walsh, Alison (Author) Liu, Ziying (Author) Hayward, Brooke (Author) Folz, Colleen (Author) Manning, Susan P. (Author) Bawa, Alicia (Author) Saracino, Lisa (Author) Thackston, Michelle (Author) Benchekroun, Youssef (Author) Capparell, Neva (Author) Wang, Mei (Author) Adair, Ron (Author) Feng, Yun (Author) Dubois, JoAnn (Author) FitzGerald, Michael G. (Author) Huang, Hui (Author) Gibson, René (Author) Allen, Kristina M. (Author) Pedan, Alex (Author) Danzig, Melvyn R. (Author) Umland, Shelby P. (Author) Egan, Robert W. (Author) Cuss, Francis M. (Author) Rorke, Steuart (Author) Clough, Joanne B. (Author) Holloway, John W. (Author) Holgate, Stephen T. (Author) Keith, Tim P. (Author) |
| Date: | 2002 |
| Additional Information: | Letters to Nature |
| Status: | Published |
| Contact Email Address: | tkeith@genomecorp.com |
| URI: | http://eprints.soton.ac.uk/id/eprint/27456 |
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