Bronchial angiogenesis in severe glucocorticoid-dependent asthma
Vrugt, B., Wilson, S., Bron, A., Holgate, S.T., Djukanovic, R. and Aalbers, R. (2000) Bronchial angiogenesis in severe glucocorticoid-dependent asthma. European Respiratory Journal, 15, (6), 1014-1021.
Download
Full text not available from this repository.
Description/Abstract
To examine the role of the bronchial microvasculature and adhesion molecule expression in severe asthma, the authors have performed an immunohistochemical study on bronchial biopsies comparing 15 glucocorticoid-dependent asthmatics, 15 mild asthmatics and eight control subjects. Serially cut glycol methacrylate-embedded sections were stained with monoclonal antibodies identifying the vessel marker EN-4, intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, E- and P-selectin. Sections were also stained for lymphocyte function associated antigen (LFA)-1 and very late antigen (VLA)-4. By comparison with mild asthma and nonasthma, severe asthma was characterized by increased numbers of submucosal vessels (p=0.009) which was associated with increased numbers of vessels expressing ICAM-1 (p=0.005). A highly significant correlation was found between the total number of EN-4+ vessels and the vessels expressing ICAM-1 (r=0.85, p=0.01). In contrast, E-selectin expression was lower in severe as compared with mild asthma (p=0.01) but not different from normal. No differences were found between the three groups in the expression of VCAM-1 and P-selectin nor in numbers of LFA-1+ and VLA-4+ cells. The results of this study support the notion that mucosal neovascularization is an important feature of airways remodelling in severe asthma. This is associated with a relatively higher density of vessels expressing intercellular adhesion molecule-1, although the expression of this adhesion molecule per vessel was not raised.
| Item Type: | Article |
|---|---|
| Related URLs: | |
| Subjects: | R Medicine |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair |
| Item ID: | 27467 |
| Date Deposited: | 26 Apr 2006 |
| Last Modified: | 01 Jun 2011 06:32 |
| Contributors: | Vrugt, B. (Author) Wilson, S. (Author) Bron, A. (Author) Holgate, S.T. (Author) Djukanovic, R. (Author) Aalbers, R. (Author) |
| Date: | 2000 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/27467 |
Actions (login required)
 |
View Item |
