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Hanging in the balance: KIR and their role in disease

Hanging in the balance: KIR and their role in disease
Hanging in the balance: KIR and their role in disease
The killer cell immunoglobulin-like receptors (KIR) are a recently discovered family of activating and inhibitory receptors that control natural killer (NK) cell function. KIR exist as a diverse family of receptors that have evolved rapidly by both gene duplication and recombination events. These findings were unexpected for a family of genes involved primarily in the innate immune response. These findings together with the observation that several of these genes have human leukocyte antigen (HLA) class I ligands, have led to a flurry of investigation into how KIR participate in viral infections, autoimmune diseases and malignancies. This review summarizes the major features of these genes and discusses how they may be involved in both disease pathogenesis and its amelioration.
1534-0384
226-240
Williams, Anthony P.
9dd1e3e0-056f-4014-b8ba-a68b21b90def
Bateman, Andrew R.
a851558d-8b9b-4020-b148-a239c2b26815
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Williams, Anthony P.
9dd1e3e0-056f-4014-b8ba-a68b21b90def
Bateman, Andrew R.
a851558d-8b9b-4020-b148-a239c2b26815
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273

Williams, Anthony P., Bateman, Andrew R. and Khakoo, Salim I. (2005) Hanging in the balance: KIR and their role in disease. Molecular Interventions, 5 (4), 226-240. (doi:10.1124/mi.5.4.6).

Record type: Article

Abstract

The killer cell immunoglobulin-like receptors (KIR) are a recently discovered family of activating and inhibitory receptors that control natural killer (NK) cell function. KIR exist as a diverse family of receptors that have evolved rapidly by both gene duplication and recombination events. These findings were unexpected for a family of genes involved primarily in the innate immune response. These findings together with the observation that several of these genes have human leukocyte antigen (HLA) class I ligands, have led to a flurry of investigation into how KIR participate in viral infections, autoimmune diseases and malignancies. This review summarizes the major features of these genes and discusses how they may be involved in both disease pathogenesis and its amelioration.

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More information

Published date: 2005
Additional Information: Review Article

Identifiers

Local EPrints ID: 27486
URI: http://eprints.soton.ac.uk/id/eprint/27486
ISSN: 1534-0384
PURE UUID: 29ae01bd-e7dc-4726-b955-5751044d3b3e
ORCID for Salim I. Khakoo: ORCID iD orcid.org/0000-0002-4057-9091

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 16 Mar 2024 03:25

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Contributors

Author: Anthony P. Williams
Author: Andrew R. Bateman
Author: Salim I. Khakoo ORCID iD

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