Analysis of novel disease-related genes in bronchial asthma
Analysis of novel disease-related genes in bronchial asthma
Bronchial asthma is a complex disease characterized by airway inflammation involving interleukin (IL)-4 and IL-13. We have applied microarray analyses to human bronchial epithelial cultures to probe for genes regulated by these cytokines and have identified a subset of disease-relevant genes by comparison with cDNA libraries derived from normal and asthmatic bronchial biopsies. Squamous cell carcinoma antigen-1 (SCCA1) and SCCA2, the cysteine and serine protease inhibitors, respectively, showed the highest expression by IL-4 and IL-13, and particularly, SCCA1 was significantly increased in the asthmatic cDNA library. STAT6 was shown to be involved in expression of SCCA1 and SCCA2 in vitro. Furthermore, serum levels of SCCA were also elevated in asthmatic patients. Taken together, it was supposed that SCCA may play some role in the pathogenesis of bronchia asthma, and measuring its serum level may be relevant for diagnosing or monitoring the status of bronchial asthma. In a complex disorder such as asthma, this combination of in vitro and in vivo genomic approaches is a powerful discriminatory method enabling identification of novel disease-related genes and their mechanisms of regulation.
bronchial epithelial cell/interleukin-4/interleukin-13/microarray/squamous cell carcinoma antigen
287-296
Yuyama, Noriko
8dfe1774-6a14-4c73-b4ca-6202d4786b1f
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Akaiwa, Mina
66b0ff9e-4283-40c2-8880-dfcd99bbacb8
Matsui, Keiko
22ef2c6c-c28d-408f-bc68-03e4b646c10c
Hamasaki, Yuhei
006d5de9-1898-408e-9956-397c47f0fc09
Suminami, Yoshinori
34b728ad-3fe8-452f-a63a-fb30d2e497aa
Yoshida, Ning Lu
c5dfd818-9467-4010-9fb1-cabaaa4298ba
Maeda, Miyako
c24aaede-2338-4478-8723-5e9a4d0f1e87
Pandit, Anita
a6cd7096-5cef-438a-a7bc-060efad3c235
Lordan, James L.
15a9bdfb-bf61-4aea-a0f4-d83868eb39d0
Kamogawa, Yumiko
c258fbcf-f940-4a02-9ca8-a79f005f0599
Arima, Kazuhiko
5998f5fa-9aa8-493c-ac97-716e1ffcfb46
Nagumo, Fumio
2b95ce5a-d162-4b2c-b583-92c2a13539a6
Sugimachi, Mitsuhiko
2977588e-92fb-4bea-b27b-b1f17e9076ac
Berger, Ann
9b11c450-b769-48aa-b8a6-6caac3fdf6c2
Richards, Ivan
479d242c-2d6e-492f-8ba2-5af61cb52fad
Roberds, Steven L.
cd4ac4b1-6bbe-4711-909b-a44e658739f6
Yamashita, Tetsuji
cf0f9e8e-bf69-49de-845a-edc3125c145f
Kishi, Fumio
cf9c7dde-979e-4e8d-83a6-8d0d235b3005
Kato, Hiroshi
78672a86-eef4-40b2-8dcb-4cb762c7556f
Arai, Ken-Ichi
283b5674-77d5-4737-bc72-639a6643c6fe
Ohshima, Koichi
5ab5f945-8c81-4b96-a266-528a6caaf1b3
Tadano, Jutaro
96f88140-45a6-4061-82c4-b69316b6bd23
Hamasaki, Ken-Ichi
8fb31176-4332-4a62-b0bb-3ead5777bc21
Miyatake, Shoichiro
de4a6880-26a3-46a6-93a1-9b5ed869d6dd
Sugita, Yuji
a7e7baf9-52b0-4be4-962c-aa4b03ae687e
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Izuhara, Kenji
78fca599-a635-4357-b0ca-7c03338f1ba5
September 2002
Yuyama, Noriko
8dfe1774-6a14-4c73-b4ca-6202d4786b1f
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Akaiwa, Mina
66b0ff9e-4283-40c2-8880-dfcd99bbacb8
Matsui, Keiko
22ef2c6c-c28d-408f-bc68-03e4b646c10c
Hamasaki, Yuhei
006d5de9-1898-408e-9956-397c47f0fc09
Suminami, Yoshinori
34b728ad-3fe8-452f-a63a-fb30d2e497aa
Yoshida, Ning Lu
c5dfd818-9467-4010-9fb1-cabaaa4298ba
Maeda, Miyako
c24aaede-2338-4478-8723-5e9a4d0f1e87
Pandit, Anita
a6cd7096-5cef-438a-a7bc-060efad3c235
Lordan, James L.
15a9bdfb-bf61-4aea-a0f4-d83868eb39d0
Kamogawa, Yumiko
c258fbcf-f940-4a02-9ca8-a79f005f0599
Arima, Kazuhiko
5998f5fa-9aa8-493c-ac97-716e1ffcfb46
Nagumo, Fumio
2b95ce5a-d162-4b2c-b583-92c2a13539a6
Sugimachi, Mitsuhiko
2977588e-92fb-4bea-b27b-b1f17e9076ac
Berger, Ann
9b11c450-b769-48aa-b8a6-6caac3fdf6c2
Richards, Ivan
479d242c-2d6e-492f-8ba2-5af61cb52fad
Roberds, Steven L.
cd4ac4b1-6bbe-4711-909b-a44e658739f6
Yamashita, Tetsuji
cf0f9e8e-bf69-49de-845a-edc3125c145f
Kishi, Fumio
cf9c7dde-979e-4e8d-83a6-8d0d235b3005
Kato, Hiroshi
78672a86-eef4-40b2-8dcb-4cb762c7556f
Arai, Ken-Ichi
283b5674-77d5-4737-bc72-639a6643c6fe
Ohshima, Koichi
5ab5f945-8c81-4b96-a266-528a6caaf1b3
Tadano, Jutaro
96f88140-45a6-4061-82c4-b69316b6bd23
Hamasaki, Ken-Ichi
8fb31176-4332-4a62-b0bb-3ead5777bc21
Miyatake, Shoichiro
de4a6880-26a3-46a6-93a1-9b5ed869d6dd
Sugita, Yuji
a7e7baf9-52b0-4be4-962c-aa4b03ae687e
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Izuhara, Kenji
78fca599-a635-4357-b0ca-7c03338f1ba5