Visual hallucinations are associated with lower alpha bungarotoxin binding in dementia with Lewy bodies
Court, J., Ballard, C., Piggot, M., Johnson, M., O'Brien, J.T, Holmes, C., Cairns, N., Lantos, P., Perry, R., Jaros, E. and Perry, E. (2001) Visual hallucinations are associated with lower alpha bungarotoxin binding in dementia with Lewy bodies. Pharmacology, Biochemistry, and Behavior, 70, (4), 571-579. (doi:10.1016/S0091-3057(01)00644-X).
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Patients with dementia with Lewy bodies (DLB) commonly experience psychotic symptoms, most notably visual hallucinations. Previously, it has been shown that visual hallucinations in DLB are associated with reduced cortical choline acetyltransferase activity, a marker of cholinergic innervation, but not with predominantly postsynaptic muscarinic M1 receptor binding. In the present investigation, nicotinic acetylcholine receptor (nAChR) levels in the temporal cortex (Brodmann's areas [BA] 20 and 36) were measured in a group of 24 prospectively assessed DLB patients; comparisons were made between groups with or without visual and auditory hallucinations and delusional misidentification. Visual hallucinations and delusional misidentification were associated with lower [125I]αbungarotoxin binding in areas 36 and 20 (P<.05), but not with changes in [3H]epibatidine binding. There were no significant associations with auditory hallucinations. [3H]epibatidine, but not [125I]αbungarotoxin, binding for all DLB cases was reduced compared to controls (P<.001). Loss of cortical α7 nicotinic receptors may contribute to hallucinations and delusional misidentification in DLB, with implications for treatment and understanding the mechanisms of psychotic symptoms in dementia.
|Digital Object Identifier (DOI):||doi:10.1016/S0091-3057(01)00644-X|
|Keywords:||nicotinic acetylcholine receptors, α7 subunits, dementia with lewy bodies, visual hallucinations, delusional misidentification, temporal cortex|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry|
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
|Date Deposited:||28 Apr 2006|
|Last Modified:||06 Aug 2015 02:28|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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