Tumour necrosis factor-αgene polymorphisms and Alzheimer's disease
Culpan, Doris, MacGowan, Sian H., Ford, Julia M., Nicoll, James A., Griffin, W. Sue, Dewar, Deborah, Cairns, Nigel J., Hughes, Anthony, Kehoe, Patrick G. and Wilcock, Gordon K. (2003) Tumour necrosis factor-αgene polymorphisms and Alzheimer's disease. Neuroscience Letters, 350, (1), 61-65. ( doi:10.1016/S0304-3940(03)00854-1).
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Recent findings suggest that production of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-α), is increased in the brains of people with Alzheimer's disease (AD). We used direct sequencing methods on a section of the enhancer/promoter region and on a smaller fragment located 10.5 kb upstream of the TNF-α gene to respectively examine TNF-α polymorphisms and TNF-a and -b microsatellite alleles in a cohort of 235 post-mortem confirmed AD and 130 control cases. None of the TNF-α point mutations or microsatellite alleles investigated proved to be independent risk factors for AD. However, when −308/A, −238/G and TNF-a2 were examined as a 2-1-2 haplotype, we observed that the absence of that haplotype was significantly associated with AD (P=0.014, Fisher's exact test) suggesting that the 2-1-2 haplotype may be protective against AD.
|Keywords:||alzheimer's disease, tumour necrosis factor-alpha, polymorphisms, hla-drb1*03|
|Subjects:||R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Q Science > QH Natural history > QH426 Genetics
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
|Date Deposited:||25 Apr 2006|
|Last Modified:||02 Mar 2012 11:26|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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