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Epidemiology of central nervous system tumors in children and young adults (0-29 years), Yorkshire, United Kingdom

Epidemiology of central nervous system tumors in children and young adults (0-29 years), Yorkshire, United Kingdom
Epidemiology of central nervous system tumors in children and young adults (0-29 years), Yorkshire, United Kingdom
The authors describe the incidence and survival of 480 patients diagnosed under 30 years with a CNS tumor in Yorkshire, UK between 1990 and 2001. The effect on survival from deprivation and other prognostic factors was examined. Young adults (aged 15–29) were significantly less likely to develop CNS tumors than children (p = .001), largely because of an excess of medulloblastoma and ependymoma in the pediatric age range. No significant temporal trends in incidence were present apart from young adults with “other CNS” tumors showing an average annual increase of 10.7% (95% CI 1.3–21.0%; p = .03). Young adults had significantly lower survival rates than children (hazard ratio = 1.52, 95%CI 1.10–2.10). The highest risk of death was observed for patients from the most affluent areas. The overall burden of CNS tumors appears to be relatively constant, but the significantly poorer survival for young people needs further rapid investigation.
adolescent, brain, central nervous system tumor, child, epidemiology
0888-0018
647-660
Feltbower, R.
efada5d7-ce80-425b-b864-3adff22b58ed
Picton, S.
5bcd76ed-c665-4a0c-825a-76ed3ae6ddae
Bridges, L.
4c6041b2-d41c-494a-9a65-cd9ea41a5c7e
Crooks, D.
339f3291-d39b-4577-abb4-138c622ed5c4
Glaser, A.
09e57b97-e655-415d-a685-14cb7909b324
McKinney, P.
5e38963f-f23f-4b86-afc4-52e710a60ddc
Feltbower, R.
efada5d7-ce80-425b-b864-3adff22b58ed
Picton, S.
5bcd76ed-c665-4a0c-825a-76ed3ae6ddae
Bridges, L.
4c6041b2-d41c-494a-9a65-cd9ea41a5c7e
Crooks, D.
339f3291-d39b-4577-abb4-138c622ed5c4
Glaser, A.
09e57b97-e655-415d-a685-14cb7909b324
McKinney, P.
5e38963f-f23f-4b86-afc4-52e710a60ddc

Feltbower, R., Picton, S., Bridges, L., Crooks, D., Glaser, A. and McKinney, P. (2004) Epidemiology of central nervous system tumors in children and young adults (0-29 years), Yorkshire, United Kingdom. Pediatric Hematology and Oncology, 21 (7), 647-660. (doi:10.1080/08880010490501079).

Record type: Article

Abstract

The authors describe the incidence and survival of 480 patients diagnosed under 30 years with a CNS tumor in Yorkshire, UK between 1990 and 2001. The effect on survival from deprivation and other prognostic factors was examined. Young adults (aged 15–29) were significantly less likely to develop CNS tumors than children (p = .001), largely because of an excess of medulloblastoma and ependymoma in the pediatric age range. No significant temporal trends in incidence were present apart from young adults with “other CNS” tumors showing an average annual increase of 10.7% (95% CI 1.3–21.0%; p = .03). Young adults had significantly lower survival rates than children (hazard ratio = 1.52, 95%CI 1.10–2.10). The highest risk of death was observed for patients from the most affluent areas. The overall burden of CNS tumors appears to be relatively constant, but the significantly poorer survival for young people needs further rapid investigation.

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More information

Published date: October 2004
Keywords: adolescent, brain, central nervous system tumor, child, epidemiology

Identifiers

Local EPrints ID: 27571
URI: http://eprints.soton.ac.uk/id/eprint/27571
ISSN: 0888-0018
PURE UUID: 3a786276-2f36-4c98-aabd-3b005262ec9b

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Date deposited: 27 Apr 2006
Last modified: 15 Mar 2024 07:19

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Contributors

Author: R. Feltbower
Author: S. Picton
Author: L. Bridges
Author: D. Crooks
Author: A. Glaser
Author: P. McKinney

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