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Long-term intracerebral inflammatory response after traumatic brain injury

Long-term intracerebral inflammatory response after traumatic brain injury
Long-term intracerebral inflammatory response after traumatic brain injury
Epidemiological and pathological studies suggest that head injury is a significant risk factor for subsequent neurodegeneration and cognitive decline in later life. The precise mechanisms for the development of post-traumatic neurodegenerative change are unclear but we hypothesize that persistence of inflammatory processes in the brain may play a key role and that some individuals are more susceptible to such changes based on their genetic make-up. In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype.
traumatic brain injury, inflammation, neurodegeneration, cytokine cycle
0379-0738
97-104
Gentleman, S.M.
5b93cc56-1fa8-4406-af6f-4177199da72a
Leclercq, P.D.
cbd9f8a0-8dfe-4714-9092-ab720a6fc141
Moyes, L.
e4c11831-4f08-400b-81c3-a8325335a4a3
Graham, D.I.
0b1c9c9e-94b2-44fa-b189-8e04501b3a67
Smith, C.
2019b8d8-ee85-40ff-9bb1-76916a21de6b
Griffin, W.S.
c1c33c3d-15aa-453c-b3d7-cf9b2256db3e
Nicoll, J.A.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Gentleman, S.M.
5b93cc56-1fa8-4406-af6f-4177199da72a
Leclercq, P.D.
cbd9f8a0-8dfe-4714-9092-ab720a6fc141
Moyes, L.
e4c11831-4f08-400b-81c3-a8325335a4a3
Graham, D.I.
0b1c9c9e-94b2-44fa-b189-8e04501b3a67
Smith, C.
2019b8d8-ee85-40ff-9bb1-76916a21de6b
Griffin, W.S.
c1c33c3d-15aa-453c-b3d7-cf9b2256db3e
Nicoll, J.A.
88c0685f-000e-4eb7-8f72-f36b4985e8ed

Gentleman, S.M., Leclercq, P.D., Moyes, L., Graham, D.I., Smith, C., Griffin, W.S. and Nicoll, J.A. (2004) Long-term intracerebral inflammatory response after traumatic brain injury. Forensic Science International, 146 (2-3), 97-104. (doi:10.1016/j.forsciint.2004.06.027).

Record type: Article

Abstract

Epidemiological and pathological studies suggest that head injury is a significant risk factor for subsequent neurodegeneration and cognitive decline in later life. The precise mechanisms for the development of post-traumatic neurodegenerative change are unclear but we hypothesize that persistence of inflammatory processes in the brain may play a key role and that some individuals are more susceptible to such changes based on their genetic make-up. In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype.

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More information

Published date: 16 December 2004
Keywords: traumatic brain injury, inflammation, neurodegeneration, cytokine cycle

Identifiers

Local EPrints ID: 27576
URI: http://eprints.soton.ac.uk/id/eprint/27576
ISSN: 0379-0738
PURE UUID: 276bfd8f-42cf-4279-a936-fa53e409c252
ORCID for J.A. Nicoll: ORCID iD orcid.org/0000-0002-9444-7246

Catalogue record

Date deposited: 26 Apr 2006
Last modified: 16 Mar 2024 03:26

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Contributors

Author: S.M. Gentleman
Author: P.D. Leclercq
Author: L. Moyes
Author: D.I. Graham
Author: C. Smith
Author: W.S. Griffin
Author: J.A. Nicoll ORCID iD

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