Neuropathological assessment of artemether-treated severe malaria
Hien, T.T. T. G., Mai, N.T., Phu, N.H., Bethell, D., Blakemore, W.F., Cavanagh, J.B., Dayan, A., Medana, I., Weller, R.O., Day, N.P. and White, N.J. (2003) Neuropathological assessment of artemether-treated severe malaria. The Lancet, 362, (9380), 295-296. (doi:10.1016/S0140-6736(03)13974-8).
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In animals, high doses of intramuscular artemether and artemotil have been shown to cause an unusual pattern of selective damage to certain brainstem nuclei, especially those implicated in hearing and balance. We aimed to investigate whether a similar pattern arises in human adults. We examined the brainstems of adults who died after treatment with high dose artemether or quinine for severe falciparum malaria for evidence of a pattern of selective neuronal damage. Neuropathological findings were similar in recipients of quinine (n=15) and artemether (n=6; total artemether doses received 4-44 mg/kg). No evidence was recorded for artemether-induced neurotoxic effects.
|Digital Object Identifier (DOI):||doi:10.1016/S0140-6736(03)13974-8|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry|
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
|Date Deposited:||27 Apr 2006|
|Last Modified:||06 Aug 2015 02:28|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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