Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation


Holmes, C., Smith, H.R., Arranz, M., Collier, D., Powell, J. and Lovestone, S. (2001) Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation. Journal of Neurology, Neurosurgery, and Psychiatry, 71, (6), 777-779.

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Description/Abstract

This study investigated possible associations between selected polymorphisms in the dopamine receptor genes DRD1 and DRD3 with the presence of psychotic phenomena or aggressive behaviour in a community based cohort of 134 patients with late onset Alzheimer's disease. An association was found between the presence of psychotic symptoms and aggressive behaviour and the DRD1 polymorphism and between the presence of psychosis, but not aggression, and the DRD3 polymorphism. Specifically, carriers of the DRD1 B2 allele were more likely to be aggressive or experience hallucinations whereas homozygous carriers of the DRD3 1 allele were more likely to experience delusions.

Item Type: Article
ISSNs: 0022-3050 (print)
Related URLs:
Keywords: alzheimers disease, genetics, behaviour
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
ePrint ID: 27592
Date Deposited: 26 Apr 2006
Last Modified: 27 Mar 2014 18:16
Contact Email Address: ch4@soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/27592

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