Depression in Alzheimer's disease: the effect of serotonin receptor gene variation


Holmes, Clive, Arranz, Maria, Collier, David, Powell, John and Lovestone, Simon (2003) Depression in Alzheimer's disease: the effect of serotonin receptor gene variation. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 119B, (1), 40-43. (doi:10.1002/ajmg.b.10068).

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Original Publication URL: http://dx.doi.org/10.1002/ajmg.b.10068

Description/Abstract

This study investigated possible associations between selected polymorphisms in the serotonin receptor genes, 5-HT2A and 5-HT2C, with the presence of co-morbid depressive illness at baseline in a community based cohort of 158 patients with late onset patients with Alzheimer's disease (AD). An association was found between the presence of major depressive illness at baseline and both the 5-HT2A and 5-HT2C polymorphisms. Specifically, homozygous carriers of the 5-HT2A C102 allele were five times more likely to have major depressive illness than heterozygotes. In addition, homozygous or hemizygous carriers of the 5-HT2C Ser allele were 12 times more likely to have major depressive illness than homozygous or hemizygous carriers of the 5-HT2C Cys allele.

Item Type: Article
Related URLs:
Keywords: genetics, behavior, 5-ht2a, 5ht2c
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Q Science > QH Natural history > QH426 Genetics
Divisions: University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
ePrint ID: 27598
Date Deposited: 25 Apr 2006
Last Modified: 27 Mar 2014 18:16
Contact Email Address: ch4@soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/27598

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