Depression in Alzheimer's disease: the effect of serotonin receptor gene variation
Holmes, Clive, Arranz, Maria, Collier, David, Powell, John and Lovestone, Simon (2003) Depression in Alzheimer's disease: the effect of serotonin receptor gene variation. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 119B, (1), 40-43. (doi:10.1002/ajmg.b.10068).
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Description/Abstract
This study investigated possible associations between selected polymorphisms in the serotonin receptor genes, 5-HT2A and 5-HT2C, with the presence of co-morbid depressive illness at baseline in a community based cohort of 158 patients with late onset patients with Alzheimer's disease (AD). An association was found between the presence of major depressive illness at baseline and both the 5-HT2A and 5-HT2C polymorphisms. Specifically, homozygous carriers of the 5-HT2A C102 allele were five times more likely to have major depressive illness than heterozygotes. In addition, homozygous or hemizygous carriers of the 5-HT2C Ser allele were 12 times more likely to have major depressive illness than homozygous or hemizygous carriers of the 5-HT2C Cys allele.
| Item Type: | Article |
|---|---|
| Related URLs: | |
| Keywords: | genetics, behavior, 5-ht2a, 5ht2c |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Q Science > QH Natural history > QH426 Genetics |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences |
| Item ID: | 27598 |
| Date Deposited: | 25 Apr 2006 |
| Last Modified: | 01 Apr 2012 02:58 |
| Contributors: | Holmes, Clive (Author) Arranz, Maria (Author) Collier, David (Author) Powell, John (Author) Lovestone, Simon (Author) |
| Date: | 2003 |
| Status: | Published |
| Contact Email Address: | ch4@soton.ac.uk |
| URI: | http://eprints.soton.ac.uk/id/eprint/27598 |
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