Long-term cognitive and functional decline in late onset Alzheimer's disease: therapeutic implications


Holmes, Clive and Lovestone, Simon (2003) Long-term cognitive and functional decline in late onset Alzheimer's disease: therapeutic implications. Age and Ageing, 32, (2), 200-204.

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Description/Abstract

Background: National Institute of Clinical Excellence guidelines advocate the use of the Mini-Mental Test Examination and a functional assessment as a means of measuring treatment response. However, there is little knowledge of the change expected in those with Alzheimer's disease in clinical practice.

Objective: to describe the long-term variability of the Mini-Mental Test Examination and Blessed Dementia Rating Scale.

Method: 374 Alzheimer's disease patients referred to psychiatric services in southeast London were followed annually over a 3-year period.

Results: the mean Mini-Mental Test Examination score for the total group at baseline was 9.9 points. Individual variability in the rate of cognitive and functional decline is large and around 40% of patients after 1 year, and up to one-quarter of patients after 3 years who survived, show no change or an improvement in scores compared with baseline measures.

Conclusions: in the evaluation of individual treatment response the rate of change, as measured by the Mini-Mental Test Examination and Blessed Dementia Rating Scale, is of limited value.

Item Type: Article
ISSNs: 0002-0729 (print)
Related URLs:
Keywords: alzheimers disease, cognitive decline, national Institute of clinical excellence, functional decline
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
ePrint ID: 27599
Date Deposited: 27 Apr 2006
Last Modified: 27 Mar 2014 18:16
URI: http://eprints.soton.ac.uk/id/eprint/27599

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