Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells


Howell, Owain W., Scharfman, Helen E., Herzog, Herbert, Sundstrom, Lars E., Beck-Sickinger, Annette and Gray, William P. (2003) Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells. Journal of Neurochemistry, 86, (3), 646-659. (doi:10.1046/j.1471-4159.2003.01895.x).

Download

Full text not available from this repository.

Description/Abstract

New neurones are produced in the adult hippocampus throughout life and are necessary for certain types of hippocampal learning. Little, however, is known about the control of hippocampal neurogenesis. We used primary hippocampal cultures from early post-natal rats and neuropeptide Y Y1 receptor knockout mice as well as selective neuropeptide Y receptor antagonists and agonists to demonstrate that neuropeptide Y is proliferative for nestin-positive, sphere-forming hippocampal precursor cells and beta-tubulin-positive neuroblasts and that the neuroproliferative effect of neuropeptide Y is mediated via its Y1 receptor. Immunohistochemistry confirmed Y1 receptor staining on both nestin-positive cells and beta-tubulin-positive cells in culture and short pulse 5-bromo-2-deoxyuridine studies demonstrated that neuropeptide Y has a proliferative effect on both cell types. These studies suggest that the proliferation of hippocampal neuroblasts and precursor cells is increased by neuropeptide Y and, therefore, that hippocampal learning and memory may be modulated by neuropeptide Y-releasing interneurones.

Item Type: Article
ISSNs: 0022-3042 (print)
Related URLs:
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
ePrint ID: 27605
Date Deposited: 27 Apr 2006
Last Modified: 27 Mar 2014 18:16
URI: http://eprints.soton.ac.uk/id/eprint/27605

Actions (login required)

View Item View Item