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Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus

Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus
Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus
Adult dentate neurogenesis is important for certain types of hippocampal-dependent learning and also appears to be important for the maintenance of normal mood and the behavioural effects of antidepressants. Neuropeptide Y (NPY), a peptide neurotransmitter released by interneurons in the dentate gyrus, has important effects on mood, anxiety-related behaviour and learning and memory. We report that adult NPY receptor knock-out mice have significantly reduced cell proliferation and significantly fewer immature doublecortin-positive neurons in the dentate gyrus. We also show that the neuroproliferative effect of NPY is dentate specific, is Y1-/-receptor mediated and involves extracellular signal-regulated kinase (ERK)1/2 activation. NPY did not exhibit any effect on cell survival in vitro but constitutive loss of the Y1 receptor in vivo resulted in greater survival of newly generated neurons and an unchanged total number of dentate granule cells. These results show that NPY stimulates neuronal precursor proliferation in the dentate gyrus and suggest that NPY-releasing interneurons may modulate dentate neurogenesis.
0022-3042
560-570
Howell, Owain W.
59b875da-844e-4738-9b3b-b9796cf3b21f
Doyle, Kharen
c7b3ace6-55a2-4570-85cd-b724e2ed0c6c
Goodman, Jeffrey H.
3a631015-c192-4f3d-beea-25a9d1e2b47e
Scharfman, Helen E.
f8c4a6d3-eb2a-4d52-93ef-7609ef4fbb9d
Herzog, Herbert
2755435a-82d7-45d0-b1db-907f0a650302
Pringle, Ashley
6339ed95-c491-43a8-b2fb-2384466dc80d
Beck-Sickinger, Annette G.
5da15634-4cc0-4df8-a30b-66d7f0ffe015
Gray, William P.
f34a0e23-3cba-4b0a-8676-a1b2c3e4c095
Howell, Owain W.
59b875da-844e-4738-9b3b-b9796cf3b21f
Doyle, Kharen
c7b3ace6-55a2-4570-85cd-b724e2ed0c6c
Goodman, Jeffrey H.
3a631015-c192-4f3d-beea-25a9d1e2b47e
Scharfman, Helen E.
f8c4a6d3-eb2a-4d52-93ef-7609ef4fbb9d
Herzog, Herbert
2755435a-82d7-45d0-b1db-907f0a650302
Pringle, Ashley
6339ed95-c491-43a8-b2fb-2384466dc80d
Beck-Sickinger, Annette G.
5da15634-4cc0-4df8-a30b-66d7f0ffe015
Gray, William P.
f34a0e23-3cba-4b0a-8676-a1b2c3e4c095

Howell, Owain W., Doyle, Kharen, Goodman, Jeffrey H., Scharfman, Helen E., Herzog, Herbert, Pringle, Ashley, Beck-Sickinger, Annette G. and Gray, William P. (2005) Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus. Journal of Neurochemistry, 93 (3), 560-570. (doi:10.1111/j.1471-4159.2005.03057.x).

Record type: Article

Abstract

Adult dentate neurogenesis is important for certain types of hippocampal-dependent learning and also appears to be important for the maintenance of normal mood and the behavioural effects of antidepressants. Neuropeptide Y (NPY), a peptide neurotransmitter released by interneurons in the dentate gyrus, has important effects on mood, anxiety-related behaviour and learning and memory. We report that adult NPY receptor knock-out mice have significantly reduced cell proliferation and significantly fewer immature doublecortin-positive neurons in the dentate gyrus. We also show that the neuroproliferative effect of NPY is dentate specific, is Y1-/-receptor mediated and involves extracellular signal-regulated kinase (ERK)1/2 activation. NPY did not exhibit any effect on cell survival in vitro but constitutive loss of the Y1 receptor in vivo resulted in greater survival of newly generated neurons and an unchanged total number of dentate granule cells. These results show that NPY stimulates neuronal precursor proliferation in the dentate gyrus and suggest that NPY-releasing interneurons may modulate dentate neurogenesis.

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Published date: 2005

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Local EPrints ID: 27606
URI: http://eprints.soton.ac.uk/id/eprint/27606
ISSN: 0022-3042
PURE UUID: 2c9f4bb3-9822-47d7-8b6f-32d923890769
ORCID for Ashley Pringle: ORCID iD orcid.org/0000-0003-2421-4380

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Date deposited: 25 Apr 2006
Last modified: 16 Mar 2024 02:48

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Contributors

Author: Owain W. Howell
Author: Kharen Doyle
Author: Jeffrey H. Goodman
Author: Helen E. Scharfman
Author: Herbert Herzog
Author: Ashley Pringle ORCID iD
Author: Annette G. Beck-Sickinger
Author: William P. Gray

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