Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men


Lehmann, D.J., Butler, H.T., Warden, D.R., Combrinck, M., King, E., Nicoll, J.A.R., Budge, M.M., de Jager, C.A., Hogervorst, E., Esiri, M.M., Ragoussis, J. and Smith, A.D. (2003) Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men. Neuroscience Letters, 340, (2), 87-90. (doi:10.1016/S0304-3940(03)00069-7). (PMID:12668243).

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Description/Abstract

We examined the CAG repeat polymorphism in exon 1 of the androgen receptor (AR) in an Oxford cohort of 150 cases (101 men) of definite or probable Alzheimer's disease (AD) and 190 elderly controls (140 men). We found that short alleles (< or = 20 CAG repeats) were associated with AD (adjusted odds ratio = 2.5, 95% confidence intervals: 1.2-5.0) in men, but not in women. This association appeared stronger in early-onset AD (< 65 years). We conclude that this AR polymorphism is of potential relevance to the risk of AD in men.

Item Type: Article
ISSNs: 0304-3940 (print)
Keywords: sex steroids, estrogen, testosterone, neuroprotection, gender, x chromosome, apolipoprotein e 4, butyrylcholinesterase k variant
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
University Structure - Pre August 2011 > School of Medicine > Community Clinical Sciences
ePrint ID: 27637
Date Deposited: 27 Apr 2006
Last Modified: 27 Mar 2014 18:16
Contact Email Address: J.Nicoll@soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/27637

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