Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men
Lehmann, D.J., Butler, H.T., Warden, D.R., Combrinck, M., King, E., Nicoll, J.A.R., Budge, M.M., de Jager, C.A., Hogervorst, E., Esiri, M.M., Ragoussis, J. and Smith, A.D. (2003) Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men. Neuroscience Letters, 340, (2), 87-90. (doi:10.1016/S0304-3940(03)00069-7). (PMID:12668243).
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Description/Abstract
We examined the CAG repeat polymorphism in exon 1 of the androgen receptor (AR) in an Oxford cohort of 150 cases (101 men) of definite or probable Alzheimer's disease (AD) and 190 elderly controls (140 men). We found that short alleles (< or = 20 CAG repeats) were associated with AD (adjusted odds ratio = 2.5, 95% confidence intervals: 1.2-5.0) in men, but not in women. This association appeared stronger in early-onset AD (< 65 years). We conclude that this AR polymorphism is of potential relevance to the risk of AD in men.
| Item Type: | Article |
|---|---|
| ISSNs: | 0304-3940 (print) |
| Keywords: | sex steroids, estrogen, testosterone, neuroprotection, gender, x chromosome, apolipoprotein e 4, butyrylcholinesterase k variant |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences University Structure - Pre August 2011 > School of Medicine > Community Clinical Sciences |
| Item ID: | 27637 |
| Date Deposited: | 27 Apr 2006 |
| Last Modified: | 08 Dec 2011 16:38 |
| Contributors: | Lehmann, D.J. (Author) Butler, H.T. (Author) Warden, D.R. (Author) Combrinck, M. (Author) King, E. (Author) Nicoll, J.A.R. (Author) Budge, M.M. (Author) de Jager, C.A. (Author) Hogervorst, E. (Author) Esiri, M.M. (Author) Ragoussis, J. (Author) Smith, A.D. (Author) |
| Date: | 10 April 2003 |
| Status: | Published |
| Contact Email Address: | J.Nicoll@soton.ac.uk |
| URI: | http://eprints.soton.ac.uk/id/eprint/27637 |
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