Genetic variation of the APOE promoter and outcome after head injury
Lendon, C. L., Harris, J.M., Pritchard, A.L., Nicoll, J.A., Teasdale, G.M. and Murray, G. (2003) Genetic variation of the APOE promoter and outcome after head injury. Neurology, 61, (5), 683-685.
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The APOE-4 allele is associated with risk for Alzheimer’s disease (AD) and poorer outcome after head injury. Several studies show that polymorphisms in the promoter that influence APOE expression also increase risk for AD. The authors’ data from a study of 92 patients are consistent with a possible influence of the G-219T promoter polymorphism on outcome after head injury. The group with unfavorable outcome had a genotype frequency distribution similar to that found in AD.
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry|
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
|Date Deposited:||27 Apr 2006|
|Last Modified:||01 Jun 2011 11:24|
|Contact Email Address:||J.Nicoll@soton.ac.uk|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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