Genetic variation of the APOE promoter and outcome after head injury


Lendon, C. L., Harris, J.M., Pritchard, A.L., Nicoll, J.A., Teasdale, G.M. and Murray, G. (2003) Genetic variation of the APOE promoter and outcome after head injury. Neurology, 61, (5), 683-685.

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Description/Abstract

The APOE-4 allele is associated with risk for Alzheimer’s disease (AD) and poorer outcome after head injury. Several studies show that polymorphisms in the promoter that influence APOE expression also increase risk for AD. The authors’ data from a study of 92 patients are consistent with a possible influence of the G-219T promoter polymorphism on outcome after head injury. The group with unfavorable outcome had a genotype frequency distribution similar to that found in AD.

Item Type: Article
ISSNs: 0028-3878 (print)
Related URLs:
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
ePrint ID: 27638
Date Deposited: 27 Apr 2006
Last Modified: 27 Mar 2014 18:16
Contact Email Address: J.Nicoll@soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/27638

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