Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage
McCarron, M.O., Weir, C.J., Muir, K.W., Hoffmann, K.L., Graffagnino, C., Nicoll, J.A., Lees, K.R. and Alberts, M.J. (2003) Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage. Acta Neurologica Scandinavica, 107, (2), 106-109. (doi:10.1034/j.1600-0404.2003.01365.x).
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Description/Abstract
Objective: to determine the relationship between the apolipoprotein E (APOE) ε4 allele and in-hospital mortality from intracerebral haemorrhage (ICH).
Material and methods: patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients.
Results: there were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOEε4 allele (P = 0.026) significantly reduced in-hospital survival.
Conclusion: the APOEε4 allele in this population may be associated with poor survival following ICH.
| Item Type: | Article |
|---|---|
| Related URLs: | |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences |
| Item ID: | 27652 |
| Date Deposited: | 28 Apr 2006 |
| Last Modified: | 01 Jun 2011 02:06 |
| Contributors: | McCarron, M.O. (Author) Weir, C.J. (Author) Muir, K.W. (Author) Hoffmann, K.L. (Author) Graffagnino, C. (Author) Nicoll, J.A. (Author) Lees, K.R. (Author) Alberts, M.J. (Author) |
| Date: | 2003 |
| Status: | Published |
| Contact Email Address: | mark.mccarron@royalhospitals.n-i.nhs.uk |
| URI: | http://eprints.soton.ac.uk/id/eprint/27652 |
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