Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage


McCarron, M.O., Weir, C.J., Muir, K.W., Hoffmann, K.L., Graffagnino, C., Nicoll, J.A., Lees, K.R. and Alberts, M.J. (2003) Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage. Acta Neurologica Scandinavica, 107, (2), 106-109. (doi:10.1034/j.1600-0404.2003.01365.x).

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Description/Abstract

Objective: to determine the relationship between the apolipoprotein E (APOE) ε4 allele and in-hospital mortality from intracerebral haemorrhage (ICH).

Material and methods: patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients.

Results: there were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOEε4 allele (P = 0.026) significantly reduced in-hospital survival.

Conclusion: the APOEε4 allele in this population may be associated with poor survival following ICH.

Item Type: Article
Related URLs:
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
ePrint ID: 27652
Date Deposited: 28 Apr 2006
Last Modified: 27 Mar 2014 18:16
URI: http://eprints.soton.ac.uk/id/eprint/27652

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