Association between interleukin-1A polymorphism and cerebral amyloid angiopathy-related hemorrhage
McCarron, M.O., Stewart, J., McCarron, P., Love, S., Vinters, H.V., Ironside, J.W., Mann, D.M., Graham, D.I. and Nicoll, J.A. (2003) Association between interleukin-1A polymorphism and cerebral amyloid angiopathy-related hemorrhage. Stroke, 34, (10), e193-e195.
Download
Full text not available from this repository.
Description/Abstract
Background and Purpose— It has been suggested that the interleukin-1A (IL-1A) allele 2 is a risk factor for Alzheimer’s disease (AD). Because cerebral amyloid angiopathy–related hemorrhage (CAAH) often coexists with AD, we examined the IL-1A polymorphism in CAAH.
Methods— In a case-control study, patients with pathologically verified CAAH, AD patients without intracerebral hemorrhage, and neuropathologically normal control subjects were studied. DNA was extracted from brain tissue, and IL-1A was genotyped. Logistic regression was used to examine the IL-1A polymorphism in CAAH patients with and without AD compared with AD and non-AD control subjects.
Results— There were 42 patients with CAAH, 232 AD patients, and 167 non-AD control subjects. In age-adjusted analyses, there was no association between possession of IL-1A allele 2 and risk of CAAH compared with AD control subjects (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.45 to 1.97; P=0.87) or non-AD control subjects (OR, 0.94; 95% CI, 0.47 to 1.87; P=0.86). Stratifying for the presence of apolipoprotein E 2 or 4 demonstrated the known increased risk of CAAH from these lipoprotein E alleles. Subgroup analyses demonstrated a nonsignificant excess of the IL-1A 2,2 genotype in patients with CAAH and AD compared with those CAAH patients who did not have histological evidence indicating AD (OR, 2.17; 95% CI, 0.15 to 122.3; P=0.64). Comparisons between CAAH patients with AD and AD control subjects and between CAAH patients without AD and non-AD control subjects did not demonstrate an association between CAAH and possession of either the IL-1A allele 2 or the 2,2 genotype.
Conclusions— The IL-1A allele 2 or 2,2 genotype does not appear to be a major risk factor for CAAH.
| Item Type: | Article |
|---|---|
| Related URLs: | |
| Keywords: | cerebral amyloid angiopathy, interleukins, intracerebral hemorrhage |
| Subjects: | R Medicine |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences |
| Item ID: | 27653 |
| Date Deposited: | 27 Apr 2006 |
| Last Modified: | 01 Jun 2011 04:15 |
| Contributors: | McCarron, M.O. (Author) Stewart, J. (Author) McCarron, P. (Author) Love, S. (Author) Vinters, H.V. (Author) Ironside, J.W. (Author) Mann, D.M. (Author) Graham, D.I. (Author) Nicoll, J.A. (Author) |
| Date: | 2003 |
| Status: | Published |
| Contact Email Address: | markmccarron@doctors.org.uk |
| URI: | http://eprints.soton.ac.uk/id/eprint/27653 |
Actions (login required)
 |
View Item |
