Involvement of apolipoprotein E in herpes simplex encephalitis

Nicoll, James A., Martin, Lee, Stewart, Janice, Murray, Lilian S., Love, Seth and Kennedy, Peter G.E. (2001) Involvement of apolipoprotein E in herpes simplex encephalitis. NeuroReport, 12, (4), 695-698.


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APOE polymorphism may influence risk for cold sores and, by interacting with latent HSV-1, risk for Alzheimer's disease (AD). APOE genotype also influences outcome after brain injury. We sought to determine whether APOE genotype influences risk for herpes simplex encephalitis (HSE), whether apoE is involved in the response to HSE and if APOE genotype influences outcome from HSE. There was increased immunoreactivity of neurons, neuropil and glia for apoE areas of brain damaged by HSE. APOE genotypes for cases of HSE (n = 57) were similar to those of controls (n = 41). APOE genotypes for survivors of HSE were similar to those of patients who died. We conclude that apoE is involved in the response to damage associated with HSE, as in other forms of brain injury. However, APOE genotype does not appear to influence either the risk of developing HSE or subsequent mortality.

Item Type: Article
Related URLs:
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions : University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
ePrint ID: 27672
Accepted Date and Publication Date:
Date Deposited: 27 Apr 2006
Last Modified: 31 Mar 2016 11:52

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