A new role for astrocytes: ?-amyloid homeostasis and degradation
A new role for astrocytes: ?-amyloid homeostasis and degradation
Accumulation of ?-amyloid protein (A?) in the brain is believed to play a key role in the pathogenesis of Alzheimer's disease (AD). There is evidence that A? accumulation might result from decreased elimination from the brain as well as from increased production, and recent work has suggested that astrocytes could have a role in A? degradation. This might lead to a better understanding of AD pathogenesis and possibly to new therapeutic avenues.
281-282
Nicoll, James A.R.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Weller, Roy O.
4a501831-e38a-4d39-a125-d7141d6c667b
2003
Nicoll, James A.R.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Weller, Roy O.
4a501831-e38a-4d39-a125-d7141d6c667b
Nicoll, James A.R. and Weller, Roy O.
(2003)
A new role for astrocytes: ?-amyloid homeostasis and degradation.
Trends in Molecular Medicine, 9 (7), .
(doi:10.1016/S1471-4914(03)00109-6).
Abstract
Accumulation of ?-amyloid protein (A?) in the brain is believed to play a key role in the pathogenesis of Alzheimer's disease (AD). There is evidence that A? accumulation might result from decreased elimination from the brain as well as from increased production, and recent work has suggested that astrocytes could have a role in A? degradation. This might lead to a better understanding of AD pathogenesis and possibly to new therapeutic avenues.
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Published date: 2003
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Local EPrints ID: 27674
URI: http://eprints.soton.ac.uk/id/eprint/27674
ISSN: 1471-4914
PURE UUID: c6b3d514-5b65-4052-957a-0a7cd1e3b79e
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Date deposited: 28 Apr 2006
Last modified: 16 Mar 2024 03:26
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Author:
Roy O. Weller
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