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Comparison of autologous serum eye drops with conventional therapy in a randomised controlled crossover trial for ocular surface disease

Comparison of autologous serum eye drops with conventional therapy in a randomised controlled crossover trial for ocular surface disease
Comparison of autologous serum eye drops with conventional therapy in a randomised controlled crossover trial for ocular surface disease
Aims: To evaluate the efficacy of 50% autologous serum drops against conventional treatment in ocular surface disorders refractory to normal treatments in a prospective randomised crossover trial.
Method: Patients fulfilling ophthalmological and haematological entry criteria were randomised to either 3 months of autologous serum 50% followed by 3 months of their conventional treatment, or 3 months of conventional treatment, followed by 3 months of autologous serum. Clinical assessments, including Schirmer’s test, rose Bengal, and fluorescein staining, were carried out on entry and at monthly intervals. Impression cytology was performed at entry, 3 and 6 months. Grading was carried out on degrees of squamous metaplasia and goblet cell density. Subjective comfort was recorded daily using the "faces" scale. These categorical scores were converted to linear measurement using Rasch analysis. Statistical analysis was carried out using Wilcoxon’s signed rank test and ANOVA.
Results: 16 patients were recruited with 31 eyes studied. The ocular surface diseases chiefly included Sjögren’s syndrome (n = 6) and keratoconjunctivitis sicca (n = 5). Impression cytology available in 25 of 31 eyes showed significant improvement on serum treatment, p<0.02. Rasch weighted faces scores were statistically significantly better with serum, p<0.01.
Conclusion: The results of this randomised study provide further evidence of the beneficial effects of autologous serum in severe ocular surface disorders. For most of these patients, autologous serum was superior to conventional treatment for improving ocular surface health and subjective comfort.
autologous serum, ocular surface disease, randomised controlled crossover trial, dry eye
0007-1161
647-652
Noble, B.A.
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Loh, R.S.
033f0fd6-e659-44aa-9390-1f57039d0f7a
MacLennan, S.
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Pesudovs, K.
c778fb7e-41d5-4e9b-b8de-4c29b6c6ea7f
Reynolds, A.
fd5d3c46-65a9-48d7-8d5d-f6da349fdb2a
Bridges, L.R.
4858d61d-57ff-4265-9164-745dc342ca4c
Burr, J.
c3114948-d8c8-4514-8508-daacd20984b3
Stewart, O.
26a08608-1012-40b7-af25-9a3a24c89d5d
Quereshi, S.
47165f8d-5722-4b43-92cf-3e0c32d22ec1
Noble, B.A.
f7fec9e7-e216-4f41-ad1c-8c15196a23f2
Loh, R.S.
033f0fd6-e659-44aa-9390-1f57039d0f7a
MacLennan, S.
0db6ce5f-7734-4d74-b40d-0bd504feaccb
Pesudovs, K.
c778fb7e-41d5-4e9b-b8de-4c29b6c6ea7f
Reynolds, A.
fd5d3c46-65a9-48d7-8d5d-f6da349fdb2a
Bridges, L.R.
4858d61d-57ff-4265-9164-745dc342ca4c
Burr, J.
c3114948-d8c8-4514-8508-daacd20984b3
Stewart, O.
26a08608-1012-40b7-af25-9a3a24c89d5d
Quereshi, S.
47165f8d-5722-4b43-92cf-3e0c32d22ec1

Noble, B.A., Loh, R.S., MacLennan, S., Pesudovs, K., Reynolds, A., Bridges, L.R., Burr, J., Stewart, O. and Quereshi, S. (2004) Comparison of autologous serum eye drops with conventional therapy in a randomised controlled crossover trial for ocular surface disease. British Journal of Ophthalmology, 88 (5), 647-652. (doi:10.1136/bjo.2003.026211).

Record type: Article

Abstract

Aims: To evaluate the efficacy of 50% autologous serum drops against conventional treatment in ocular surface disorders refractory to normal treatments in a prospective randomised crossover trial.
Method: Patients fulfilling ophthalmological and haematological entry criteria were randomised to either 3 months of autologous serum 50% followed by 3 months of their conventional treatment, or 3 months of conventional treatment, followed by 3 months of autologous serum. Clinical assessments, including Schirmer’s test, rose Bengal, and fluorescein staining, were carried out on entry and at monthly intervals. Impression cytology was performed at entry, 3 and 6 months. Grading was carried out on degrees of squamous metaplasia and goblet cell density. Subjective comfort was recorded daily using the "faces" scale. These categorical scores were converted to linear measurement using Rasch analysis. Statistical analysis was carried out using Wilcoxon’s signed rank test and ANOVA.
Results: 16 patients were recruited with 31 eyes studied. The ocular surface diseases chiefly included Sjögren’s syndrome (n = 6) and keratoconjunctivitis sicca (n = 5). Impression cytology available in 25 of 31 eyes showed significant improvement on serum treatment, p<0.02. Rasch weighted faces scores were statistically significantly better with serum, p<0.01.
Conclusion: The results of this randomised study provide further evidence of the beneficial effects of autologous serum in severe ocular surface disorders. For most of these patients, autologous serum was superior to conventional treatment for improving ocular surface health and subjective comfort.

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More information

Published date: May 2004
Keywords: autologous serum, ocular surface disease, randomised controlled crossover trial, dry eye

Identifiers

Local EPrints ID: 27677
URI: http://eprints.soton.ac.uk/id/eprint/27677
ISSN: 0007-1161
PURE UUID: a19e2d23-5057-46e0-a068-dcb632d7b419

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Date deposited: 27 Apr 2006
Last modified: 15 Mar 2024 07:20

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Contributors

Author: B.A. Noble
Author: R.S. Loh
Author: S. MacLennan
Author: K. Pesudovs
Author: A. Reynolds
Author: L.R. Bridges
Author: J. Burr
Author: O. Stewart
Author: S. Quereshi

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