Tau immunohistochemistry in acute brain injury
Smith, C., Graham, D.I., Murray, L.S. and Nicoll, J.A.R. (2003) Tau immunohistochemistry in acute brain injury. Neuropathology and Applied Neurobiology, 29, (5), 496-502. (doi:10.1046/j.1365-2990.2003.00488.x).
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Epidemiological studies have identified a history of head injury as a risk factor for Alzheimer's disease. However, the neuropathological mechanism underlying this relationship is as yet unclear. Neuronal cytoskeletal changes in the form of neurofibrillary tangles and neuropil threads have recently been demonstrated in young men who had sustained repetitive head injury and subsequently died in their 20s. In addition, recent experimental studies have found accumulation of tau within neuronal somata and damaged axons following diffuse brain injury. We hypothesized that tau-immunoreactive tangles may be present in the brains of patients who died after a single acute blunt head injury. A total of 45 cases of fatal head injury were immunostained for tau. They comprised nine groups (n = 5 for each group) separated by age (0–19 years, 20–50 years, 50 + years) and survival time (< 24 h, 24 h−1 week, 1 week−1 month) and were compared with age-matched controls. Subtle alterations in tau immunoreactivity, for example, in oligodendrocytes, were present in some head injury cases but not controls. However, neurofibrillary tangles did not appear more prevalent after traumatic brain injury (TBI) when compared with age-matched controls. Although alterations in tau immunoreactivity may occur which warrant further study, neurofibrillary tangles were not more prevalent after a single fatal episode of TBI.
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry|
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
|Date Deposited:||28 Apr 2006|
|Last Modified:||01 Jun 2011 14:08|
|Contact Email Address:||firstname.lastname@example.org|
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