Apolipoprotein E genotype, coagulation, and survival following acute stroke

Weir, C.J., McCarron, M.O., Muir, K.W., Dyker, A.G., Bone, I., Lees, K.R. and Nicoll, J.A. (2001) Apolipoprotein E genotype, coagulation, and survival following acute stroke. Neurology, 57, (6), 1097-1100.


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The authors hypothesized that divergent influences of the APOE ε4 allele on ischemic and hemorrhagic stroke survival might result from differences in coagulation profiles. In 49 hemorrhagic stroke patients, ε4 carriers had higher partial thromboplastin time ratios (p < 0.01) than non-ε4 carriers. Among 529 ischemic stroke patients, increasing ε4 allele dose was associated with improved survival (p = 0.03) after adjusting for baseline NIH stroke scale (p = 0.00001) and partial thromboplastin time ratio (p = 0.01). Relative anticoagulation does not fully explain the survival advantage in ε4-carrying ischemic stroke patients.

Item Type: Article
ISSNs: 0028-3878 (print)
Related URLs:
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Q Science > QH Natural history > QH426 Genetics
Divisions: University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
ePrint ID: 27737
Date Deposited: 27 Apr 2006
Last Modified: 27 Mar 2014 18:16
URI: http://eprints.soton.ac.uk/id/eprint/27737

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