Apolipoprotein E genotype, coagulation, and survival following acute stroke
Apolipoprotein E genotype, coagulation, and survival following acute stroke
The authors hypothesized that divergent influences of the APOE ?4 allele on ischemic and hemorrhagic stroke survival might result from differences in coagulation profiles. In 49 hemorrhagic stroke patients, ?4 carriers had higher partial thromboplastin time ratios (p < 0.01) than non-?4 carriers. Among 529 ischemic stroke patients, increasing ?4 allele dose was associated with improved survival (p = 0.03) after adjusting for baseline NIH stroke scale (p = 0.00001) and partial thromboplastin time ratio (p = 0.01). Relative anticoagulation does not fully explain the survival advantage in ?4-carrying ischemic stroke patients.
1097-1100
Weir, C.J.
c3d2c5ad-6881-40bc-b36c-88afaa438e00
McCarron, M.O.
49985d16-f2e0-4d44-aad0-2591fcbeb4c3
Muir, K.W.
a3a4bfa8-60a6-4ed3-9a7e-4619256f3c4f
Dyker, A.G.
b68f1209-9982-41d7-8b82-6797d691bde4
Bone, I.
ec90809a-6cb3-4634-bc56-a6ed0abcc74b
Lees, K.R.
29f45d51-fc58-4f1a-9c16-a31950868daf
Nicoll, J.A.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
September 2001
Weir, C.J.
c3d2c5ad-6881-40bc-b36c-88afaa438e00
McCarron, M.O.
49985d16-f2e0-4d44-aad0-2591fcbeb4c3
Muir, K.W.
a3a4bfa8-60a6-4ed3-9a7e-4619256f3c4f
Dyker, A.G.
b68f1209-9982-41d7-8b82-6797d691bde4
Bone, I.
ec90809a-6cb3-4634-bc56-a6ed0abcc74b
Lees, K.R.
29f45d51-fc58-4f1a-9c16-a31950868daf
Nicoll, J.A.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Weir, C.J., McCarron, M.O., Muir, K.W., Dyker, A.G., Bone, I., Lees, K.R. and Nicoll, J.A.
(2001)
Apolipoprotein E genotype, coagulation, and survival following acute stroke.
Neurology, 57 (6), .
Abstract
The authors hypothesized that divergent influences of the APOE ?4 allele on ischemic and hemorrhagic stroke survival might result from differences in coagulation profiles. In 49 hemorrhagic stroke patients, ?4 carriers had higher partial thromboplastin time ratios (p < 0.01) than non-?4 carriers. Among 529 ischemic stroke patients, increasing ?4 allele dose was associated with improved survival (p = 0.03) after adjusting for baseline NIH stroke scale (p = 0.00001) and partial thromboplastin time ratio (p = 0.01). Relative anticoagulation does not fully explain the survival advantage in ?4-carrying ischemic stroke patients.
Text
00006114-200109250-00034.pdf
- Version of Record
Restricted to Repository staff only
Request a copy
More information
Published date: September 2001
Identifiers
Local EPrints ID: 27737
URI: http://eprints.soton.ac.uk/id/eprint/27737
ISSN: 0028-3878
PURE UUID: 5e963d57-69a1-4717-bd13-606875fc7184
Catalogue record
Date deposited: 27 Apr 2006
Last modified: 16 Mar 2024 03:26
Export record
Contributors
Author:
C.J. Weir
Author:
M.O. McCarron
Author:
K.W. Muir
Author:
A.G. Dyker
Author:
I. Bone
Author:
K.R. Lees
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
