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A systems modelling approach for the prevention and treatment of diabetic retinopathy

A systems modelling approach for the prevention and treatment of diabetic retinopathy
A systems modelling approach for the prevention and treatment of diabetic retinopathy
Diabetic patients may suffer from a number of long-term complications. One such complication is the onset of diabetic retinopathy, which damages the eyes and can lead to blindness. We describe the use of a systems modelling approach for the progression of diabetic retinopathy that has been used for cost-effectiveness evaluations of various prevention and patient care options. The adopted framework incorporates retinopathy risk groupings, created using classification and regression tree (CART) analysis, which are then fed into a developed simulation model, at the level of individual diabetic patients. A multidisciplinary task group, comprising of clinicians and health care modellers, guided the necessary modular development involving the definition of risk groups in the community, natural history of diabetic retinopathy, and options for early detection and treatment. Data has been taken from a prospective Wellcome Diabetes Study at the Diabetes Unit, King Edward Memorial Hospital, Pune, India. India has the highest number of diabetic patients in any one country, approximately 25 million in 2000, and this number is predicted to rise to 57 million by the year 2025.
0377-2217
81-91
Harper, P.
93a9f992-d1de-4748-b77a-00917cf3e879
Sayyad, M.
e919fedc-1424-41dd-bb2d-51f7e3471980
de Senna, V.
97754892-ac68-4e10-bacc-499275c22b39
Shahani, A.
01f30d3f-6d62-4c19-8a3e-e4d223559dc7
Yajnik, C.
8ed2bf3e-23b0-4360-8328-ba6ee924bb81
Shelgikar, K.
80390e44-e50f-4f65-afd9-6d4f4aabfdf3
Harper, P.
93a9f992-d1de-4748-b77a-00917cf3e879
Sayyad, M.
e919fedc-1424-41dd-bb2d-51f7e3471980
de Senna, V.
97754892-ac68-4e10-bacc-499275c22b39
Shahani, A.
01f30d3f-6d62-4c19-8a3e-e4d223559dc7
Yajnik, C.
8ed2bf3e-23b0-4360-8328-ba6ee924bb81
Shelgikar, K.
80390e44-e50f-4f65-afd9-6d4f4aabfdf3

Harper, P., Sayyad, M., de Senna, V., Shahani, A., Yajnik, C. and Shelgikar, K. (2003) A systems modelling approach for the prevention and treatment of diabetic retinopathy. European Journal of Operational Research, 150 (1), 81-91. (doi:10.1016/S0377-2217(02)00787-7).

Record type: Article

Abstract

Diabetic patients may suffer from a number of long-term complications. One such complication is the onset of diabetic retinopathy, which damages the eyes and can lead to blindness. We describe the use of a systems modelling approach for the progression of diabetic retinopathy that has been used for cost-effectiveness evaluations of various prevention and patient care options. The adopted framework incorporates retinopathy risk groupings, created using classification and regression tree (CART) analysis, which are then fed into a developed simulation model, at the level of individual diabetic patients. A multidisciplinary task group, comprising of clinicians and health care modellers, guided the necessary modular development involving the definition of risk groups in the community, natural history of diabetic retinopathy, and options for early detection and treatment. Data has been taken from a prospective Wellcome Diabetes Study at the Diabetes Unit, King Edward Memorial Hospital, Pune, India. India has the highest number of diabetic patients in any one country, approximately 25 million in 2000, and this number is predicted to rise to 57 million by the year 2025.

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More information

Published date: 2003
Organisations: Operational Research

Identifiers

Local EPrints ID: 29697
URI: http://eprints.soton.ac.uk/id/eprint/29697
ISSN: 0377-2217
PURE UUID: b20e1483-6118-48e0-9d28-fe9369ab05ec

Catalogue record

Date deposited: 12 May 2006
Last modified: 15 Mar 2024 07:34

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Contributors

Author: P. Harper
Author: M. Sayyad
Author: V. de Senna
Author: A. Shahani
Author: C. Yajnik
Author: K. Shelgikar

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