Melanocortin 1 receptor gene and sun sensitivity in individuals without red hair
Melanocortin 1 receptor gene and sun sensitivity in individuals without red hair
Susceptibility to sunburn, photoageing, and skin cancer is inversely related to an individual’s ability to tan after sun exposure. We examined variants in the melanocortin-1-receptor (MC1R) gene in individuals from Ireland and the UK. We found evidence of an association between the degree of tanning after repeated sun exposure, and the number of variant alleles present. Heterozygotes were intermediate between wild-type individuals and those with two variant alleles. We suggest that MC1R gene status therefore determines sun sensitivity in people without red hair.
1072-1073
Flanagan, Niamh
2d37f079-81df-4145-8833-5cfa215c215d
Ray, Amanda
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Todd, Carole
842f0b28-f5b7-4af2-8ad8-5f2b2aa5f395
Jackson, Ian J.
deb175b7-f77e-4b60-b8a9-472ef9cb6770
Matthews, John N. S.
9aa54b66-2926-400f-bf0c-1e6208f4ab53
Birch-Machin, Mark A.
1bd387dd-9082-40bf-8ab3-f898bc68fc76
Rees, Jonathan L.
8a58a967-d239-4300-b363-ca471bf7047f
25 March 2000
Flanagan, Niamh
2d37f079-81df-4145-8833-5cfa215c215d
Ray, Amanda
541e873e-6ff6-427a-8044-f6852b46de89
Todd, Carole
842f0b28-f5b7-4af2-8ad8-5f2b2aa5f395
Jackson, Ian J.
deb175b7-f77e-4b60-b8a9-472ef9cb6770
Matthews, John N. S.
9aa54b66-2926-400f-bf0c-1e6208f4ab53
Birch-Machin, Mark A.
1bd387dd-9082-40bf-8ab3-f898bc68fc76
Rees, Jonathan L.
8a58a967-d239-4300-b363-ca471bf7047f
Healy, Eugene, Flanagan, Niamh, Ray, Amanda, Todd, Carole, Jackson, Ian J., Matthews, John N. S., Birch-Machin, Mark A. and Rees, Jonathan L.
(2000)
Melanocortin 1 receptor gene and sun sensitivity in individuals without red hair.
Lancet, 355 (9209), .
(PMID:10744096)
Abstract
Susceptibility to sunburn, photoageing, and skin cancer is inversely related to an individual’s ability to tan after sun exposure. We examined variants in the melanocortin-1-receptor (MC1R) gene in individuals from Ireland and the UK. We found evidence of an association between the degree of tanning after repeated sun exposure, and the number of variant alleles present. Heterozygotes were intermediate between wild-type individuals and those with two variant alleles. We suggest that MC1R gene status therefore determines sun sensitivity in people without red hair.
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Published date: 25 March 2000
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 334304
URI: http://eprints.soton.ac.uk/id/eprint/334304
ISSN: 0140-6736
PURE UUID: 3c3d706f-fee3-4901-9e81-a1c5e05f5e82
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Date deposited: 08 Mar 2012 12:53
Last modified: 22 Jul 2022 18:01
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Contributors
Author:
Eugene Healy
Author:
Niamh Flanagan
Author:
Amanda Ray
Author:
Carole Todd
Author:
Ian J. Jackson
Author:
John N. S. Matthews
Author:
Mark A. Birch-Machin
Author:
Jonathan L. Rees
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