Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Blood pressure is a heritable trait1 influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension ($140mmHg systolic blood pressure or$90mmHg diastolic blood pressure)2. Even small increments in blood pressure are associated with an increased risk of cardiovascular events3. This genome-wide association
study of systolic and diastolic blood pressure, which used
a multi-stage design in 200,000 individuals of European descent,identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure(GUCY1A3–GUCY1B3, NPR3–C5orf23, ADM, FURIN–FES, GOSR2, GNAS–EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genomewide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest
potential novel therapeutic pathways for cardiovascular disease prevention.
103-109
Roderick, P.
dbb3cd11-4c51-4844-982b-0eb30ad5085a
International Consortium for Blood Pressure Genome-Wide Association Studies
6 October 2011
Roderick, P.
dbb3cd11-4c51-4844-982b-0eb30ad5085a
Roderick, P.
,
International Consortium for Blood Pressure Genome-Wide Association Studies
(2011)
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
Nature, 478 (7367), .
(doi:10.1038/nature10405).
(PMID:21909115)
Abstract
Blood pressure is a heritable trait1 influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension ($140mmHg systolic blood pressure or$90mmHg diastolic blood pressure)2. Even small increments in blood pressure are associated with an increased risk of cardiovascular events3. This genome-wide association
study of systolic and diastolic blood pressure, which used
a multi-stage design in 200,000 individuals of European descent,identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure(GUCY1A3–GUCY1B3, NPR3–C5orf23, ADM, FURIN–FES, GOSR2, GNAS–EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genomewide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest
potential novel therapeutic pathways for cardiovascular disease prevention.
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e-pub ahead of print date: 11 September 2011
Published date: 6 October 2011
Organisations:
Primary Care & Population Sciences
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Local EPrints ID: 335554
URI: http://eprints.soton.ac.uk/id/eprint/335554
ISSN: 0028-0836
PURE UUID: 5aaeb46c-6fb9-434a-9c16-98258c3af156
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Date deposited: 20 Mar 2012 10:20
Last modified: 15 Mar 2024 02:49
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Corporate Author: International Consortium for Blood Pressure Genome-Wide Association Studies
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