Natural killer cell responses during viral infections: flexibility and conditioning of innate immunity by experience


Vidal, Silvia M., Khakoo, Salim I. and Biron, Christine A. (2011) Natural killer cell responses during viral infections: flexibility and conditioning of innate immunity by experience. Current Opinion in Virology, 1, (6), 497-512. (doi:10.1016/j.coviro.2011.10.017). (PMID:22180766).

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Description/Abstract

Natural killer (NK) cells mediate innate defense against viral infections, but the mechanisms in place to access their functions as needed during diverse challenges while limiting collateral damage are poorly understood. Recent molecular characterization of effects mediated through infection-induced inhibitory/activating NK receptor-ligand pairs and cytokines are providing new insights into pathways regulating their responses and revealing unexpected consequences for NK cell subset effects, maintenance, proliferation and function through times overlapping with adaptive and long-lived immunity. The observations define flexible pathways for experience-induced "conditioning" and challenge narrowly defined roles for NK cells and innate immunity as first responders with prescribed functions. They suggest that individual experiences as well as genes influence the innate immune resources available to fight off an infection.

Item Type: Article
ISSNs: 1879-6257 (electronic)
Keywords: natural killer (NK) cells, virology
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RC Internal medicine
Divisions: Faculty of Medicine > Infection, Inflammation and Immunity
ePrint ID: 336167
Date Deposited: 16 Mar 2012 11:13
Last Modified: 27 Mar 2014 20:19
URI: http://eprints.soton.ac.uk/id/eprint/336167

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