KIR2DL2 enhances protective and detrimental HLA class I-mediated immunity in chronic viral infection
KIR2DL2 enhances protective and detrimental HLA class I-mediated immunity in chronic viral infection
Killer cell immunoglobulin-like receptors (KIRs) influence both innate and adaptive immunity. But while the role of KIRs in NK-mediated innate immunity is well-documented, the impact of KIRs on the T cell response in human disease is not known. Here we test the hypothesis that an individual's KIR genotype affects the efficiency of their HLA class I-mediated antiviral immune response and the outcome of viral infection. We show that, in two unrelated viral infections, hepatitis C virus and human T lymphotropic virus type 1, possession of the KIR2DL2 gene enhanced both protective and detrimental HLA class I-restricted anti-viral immunity. These results reveal a novel role for inhibitory KIRs. We conclude that inhibitory KIRs, in synergy with T cells, are a major determinant of the outcome of persistent viral infection.
1002270-[12pp]
Seich Al Basatena, Nafisa-Katrin
eccef1ae-16c3-4fe3-936f-5c4cde34ba50
MacNamara, Aidan
cd879517-ae79-483c-bbde-bf6570395483
Vine, Alison M.
c2c874ca-de9b-4346-b9ae-b4059245da34
Thio, Chloe L.
9bb90dbe-60a7-4574-b16a-33d7a3ecb07b
Astemborski, Jacquie
75ec0057-6f26-4a4c-9ea2-206d08b0be65
Usuku, Koichiro
800c9d6c-39d9-4dcd-9208-3548f788944a
Osame, Mitsuhiro
cbba489b-57e2-47a9-850f-83e93d3f66b8
Kirk, Gregory D.
562ddcaa-f2c2-4e06-b87e-08e99b0e1244
Donfield, Sharyne M.
8740abaf-75d3-4158-9f0a-9f3d8ee8cb1f
Goedert, James J.
d28c5645-6f66-4763-8527-662cde9a8c13
Bangham, Charles R.M.
dd337c8f-bb2f-4edb-a44c-f58cba89db15
Carrington, Mary
0fd214c9-4cbc-4719-9d75-9997cd474bd8
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Asquith, Becca
0aa826a6-5c95-4a3e-84ab-033f1fc76050
13 October 2011
Seich Al Basatena, Nafisa-Katrin
eccef1ae-16c3-4fe3-936f-5c4cde34ba50
MacNamara, Aidan
cd879517-ae79-483c-bbde-bf6570395483
Vine, Alison M.
c2c874ca-de9b-4346-b9ae-b4059245da34
Thio, Chloe L.
9bb90dbe-60a7-4574-b16a-33d7a3ecb07b
Astemborski, Jacquie
75ec0057-6f26-4a4c-9ea2-206d08b0be65
Usuku, Koichiro
800c9d6c-39d9-4dcd-9208-3548f788944a
Osame, Mitsuhiro
cbba489b-57e2-47a9-850f-83e93d3f66b8
Kirk, Gregory D.
562ddcaa-f2c2-4e06-b87e-08e99b0e1244
Donfield, Sharyne M.
8740abaf-75d3-4158-9f0a-9f3d8ee8cb1f
Goedert, James J.
d28c5645-6f66-4763-8527-662cde9a8c13
Bangham, Charles R.M.
dd337c8f-bb2f-4edb-a44c-f58cba89db15
Carrington, Mary
0fd214c9-4cbc-4719-9d75-9997cd474bd8
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Asquith, Becca
0aa826a6-5c95-4a3e-84ab-033f1fc76050
Seich Al Basatena, Nafisa-Katrin, MacNamara, Aidan, Vine, Alison M., Thio, Chloe L., Astemborski, Jacquie, Usuku, Koichiro, Osame, Mitsuhiro, Kirk, Gregory D., Donfield, Sharyne M., Goedert, James J., Bangham, Charles R.M., Carrington, Mary, Khakoo, Salim I. and Asquith, Becca
(2011)
KIR2DL2 enhances protective and detrimental HLA class I-mediated immunity in chronic viral infection.
PLOS Pathogens, 7 (10), .
(doi:10.1371/journal.ppat.1002270).
(PMID:22022261)
Abstract
Killer cell immunoglobulin-like receptors (KIRs) influence both innate and adaptive immunity. But while the role of KIRs in NK-mediated innate immunity is well-documented, the impact of KIRs on the T cell response in human disease is not known. Here we test the hypothesis that an individual's KIR genotype affects the efficiency of their HLA class I-mediated antiviral immune response and the outcome of viral infection. We show that, in two unrelated viral infections, hepatitis C virus and human T lymphotropic virus type 1, possession of the KIR2DL2 gene enhanced both protective and detrimental HLA class I-restricted anti-viral immunity. These results reveal a novel role for inhibitory KIRs. We conclude that inhibitory KIRs, in synergy with T cells, are a major determinant of the outcome of persistent viral infection.
Other
fetchObject.action_uri=info_doi%2F10.1371%2Fjournal.ppat.1002270&representation=PDF
- Version of Record
Available under License Other.
More information
Published date: 13 October 2011
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 336168
URI: http://eprints.soton.ac.uk/id/eprint/336168
ISSN: 1553-7366
PURE UUID: c00dee3b-14d7-44e4-a94e-24259e821c9e
Catalogue record
Date deposited: 16 Mar 2012 11:56
Last modified: 15 Mar 2024 03:12
Export record
Altmetrics
Contributors
Author:
Nafisa-Katrin Seich Al Basatena
Author:
Aidan MacNamara
Author:
Alison M. Vine
Author:
Chloe L. Thio
Author:
Jacquie Astemborski
Author:
Koichiro Usuku
Author:
Mitsuhiro Osame
Author:
Gregory D. Kirk
Author:
Sharyne M. Donfield
Author:
James J. Goedert
Author:
Charles R.M. Bangham
Author:
Mary Carrington
Author:
Becca Asquith
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
