Natural killer cells and hepatitis C: action and reaction
Cheent, Kuldeep and Khakoo, Salim I. (2011) Natural killer cells and hepatitis C: action and reaction. Gut, 60, (2), 268-278. (doi:10.1136/gut.2010.212555). (PMID:20876777).
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Description/Abstract
In 1989, hepatitis C virus (HCV) was first identified as the infectious agent responsible for human non-A, non-B hepatitis. Two decades later, HCV remains a global public health problem with a suboptimal response rate to treatment and the absence of a protective vaccine. Recent work has highlighted the influence of the innate immune system, and in particular natural killer cells, on the outcome and pathology of HCV infection. These cells are considerably more complex than was originally thought and their role in viral infections is currently being unravelled. This review summarises our emerging understanding of natural killer cells in HCV infection.
| Item Type: | Article |
|---|---|
| ISSNs: | 0017-5749 (print) |
| Keywords: | natural killer cells, immunology, hepatitis C |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology Q Science > QR Microbiology > QR355 Virology R Medicine > RB Pathology |
| Divisions: | Faculty of Medicine > Infection, Inflammation and Immunity |
| Item ID: | 336177 |
| Date Deposited: | 16 Mar 2012 12:55 |
| Last Modified: | 16 Mar 2012 12:55 |
| Contributors: | Cheent, Kuldeep (Author) Khakoo, Salim I. (Author) |
| Date: | February 2011 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/336177 |
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