Natural killer cells and hepatitis C: action and reaction

Cheent, Kuldeep and Khakoo, Salim I. (2011) Natural killer cells and hepatitis C: action and reaction. Gut, 60, (2), 268-278. (doi:10.1136/gut.2010.212555). (PMID:20876777).


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In 1989, hepatitis C virus (HCV) was first identified as the infectious agent responsible for human non-A, non-B hepatitis. Two decades later, HCV remains a global public health problem with a suboptimal response rate to treatment and the absence of a protective vaccine. Recent work has highlighted the influence of the innate immune system, and in particular natural killer cells, on the outcome and pathology of HCV infection. These cells are considerably more complex than was originally thought and their role in viral infections is currently being unravelled. This review summarises our emerging understanding of natural killer cells in HCV infection.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1136/gut.2010.212555
ISSNs: 0017-5749 (print)
Keywords: natural killer cells, immunology, hepatitis C
Subjects: Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology > QR355 Virology
R Medicine > RB Pathology
Divisions : Faculty of Medicine > Clinical and Experimental Sciences
ePrint ID: 336177
Accepted Date and Publication Date:
February 2011Published
Date Deposited: 16 Mar 2012 12:55
Last Modified: 31 Mar 2016 14:24

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