Speed and selection in the evolution of killer-cell immunoglobulin-like receptors

Martinez-Borra, J. and Khakoo, Salim I. (2008) Speed and selection in the evolution of killer-cell immunoglobulin-like receptors. International Journal of Immunogenetics, 35, (2), 89-96. (doi:10.1111/j.1744-313X.2008.00756.x). (PMID:18279370).


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The killer-cell immunoglobulin-like receptors (KIR) form a diverse family of receptors that control the functions of natural killer cells. Sequencing of KIR from primates has revealed the unexpected extent to which this gene family has diversified mostly likely in response to pathogens and to pathogen-mediated selection of their MHC class I ligands. Human KIR diversity is now a burgeoning area for disease association studies. This review examines the evolution of KIR from a primate-centric view in order to rationalize our current knowledge of the diversity of human KIR.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1111/j.1744-313X.2008.00756.x
ISSNs: 1744-3121 (print)
1744-313X (electronic)
Keywords: KIR receptors, natural killer cells
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology > QR355 Virology
Divisions : Faculty of Medicine > Clinical and Experimental Sciences
ePrint ID: 336186
Accepted Date and Publication Date:
April 2008Published
12 February 2008Made publicly available
Date Deposited: 16 Mar 2012 15:20
Last Modified: 31 Mar 2016 14:24
URI: http://eprints.soton.ac.uk/id/eprint/336186

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