The University of Southampton
University of Southampton Institutional Repository

KIR and disease: a model system or system of models?

KIR and disease: a model system or system of models?
KIR and disease: a model system or system of models?
The discovery of an unexpected level of diversity among the killer cell immunoglobulin-like receptors has led to a search for their role in human disease. Due to their polymorphism and also that of their human leukocyte antigen class I ligands, these studies are difficult to perform and complex to interpret. Nevertheless, as the number of data sets increase, consistent trends and themes are beginning to emerge in both viral and inflammatory disorders. In this review, we summarize the findings from a number of disease association studies and discuss these in the context of the activating and inhibitory roles of the members of this gene family.
KIR–HLA interactions, natural killer cells, haplotypic diversity, genetic association studies
0105-2896
186-201
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Carrington, Mary
0fd214c9-4cbc-4719-9d75-9997cd474bd8
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Carrington, Mary
0fd214c9-4cbc-4719-9d75-9997cd474bd8

Khakoo, Salim I. and Carrington, Mary (2006) KIR and disease: a model system or system of models? Immunological Reviews, 214 (1), 186-201. (doi:10.1111/j.1600-065X.2006.00459.x). (PMID:17100885)

Record type: Article

Abstract

The discovery of an unexpected level of diversity among the killer cell immunoglobulin-like receptors has led to a search for their role in human disease. Due to their polymorphism and also that of their human leukocyte antigen class I ligands, these studies are difficult to perform and complex to interpret. Nevertheless, as the number of data sets increase, consistent trends and themes are beginning to emerge in both viral and inflammatory disorders. In this review, we summarize the findings from a number of disease association studies and discuss these in the context of the activating and inhibitory roles of the members of this gene family.

This record has no associated files available for download.

More information

e-pub ahead of print date: 7 November 2006
Published date: December 2006
Keywords: KIR–HLA interactions, natural killer cells, haplotypic diversity, genetic association studies
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 336187
URI: http://eprints.soton.ac.uk/id/eprint/336187
ISSN: 0105-2896
PURE UUID: e25277a4-0dd7-491b-bb91-8aeafe8ad877
ORCID for Salim I. Khakoo: ORCID iD orcid.org/0000-0002-4057-9091

Catalogue record

Date deposited: 16 Mar 2012 15:03
Last modified: 15 Mar 2024 03:12

Export record

Altmetrics

Contributors

Author: Salim I. Khakoo ORCID iD
Author: Mary Carrington

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×