KIR and disease: a model system or system of models?

Khakoo, Salim I. and Carrington, Mary (2006) KIR and disease: a model system or system of models? Immunological Reviews, 214, (1), 186-201. (doi:10.1111/j.1600-065X.2006.00459.x). (PMID:17100885).


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The discovery of an unexpected level of diversity among the killer cell immunoglobulin-like receptors has led to a search for their role in human disease. Due to their polymorphism and also that of their human leukocyte antigen class I ligands, these studies are difficult to perform and complex to interpret. Nevertheless, as the number of data sets increase, consistent trends and themes are beginning to emerge in both viral and inflammatory disorders. In this review, we summarize the findings from a number of disease association studies and discuss these in the context of the activating and inhibitory roles of the members of this gene family.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1111/j.1600-065X.2006.00459.x
ISSNs: 0105-2896 (print)
1600-065X (electronic)
Keywords: KIR–HLA interactions, natural killer cells, haplotypic diversity, genetic association studies
Subjects: Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology > QR355 Virology
R Medicine > RB Pathology
Divisions : Faculty of Medicine > Clinical and Experimental Sciences
ePrint ID: 336187
Accepted Date and Publication Date:
December 2006Published
7 November 2006Made publicly available
Date Deposited: 16 Mar 2012 15:03
Last Modified: 31 Mar 2016 14:24

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