Thin film polycrystalline silicon nanowire biosensors


Al Hakim, Mohammad M., Lombardini, Marta, Sun, Kai, Giustiniano, Francesco, Roach, Peter L., Davies, Donna E., Howarth, Peter H., de Planque, Maurits R.R., Morgan, Hywel and Ashburn, Peter (2012) Thin film polycrystalline silicon nanowire biosensors. Nano Letters, 12, (4), 1868-1872. (doi:10.1021/nl2042276). (PMID:22432636).

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Description/Abstract

Polysilicon nanowire biosensors have been fabricated using a top-down process and were used to determine the binding constant of two inflammatory biomarkers. A very low cost nanofabrication process was developed, based on simple and mature photolithography, thin film technology and plasma etching, enabling an easy route to mass manufacture. Antibodyfunctionalized nanowire sensors were used to detect the proteins interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) over a wide range of concentrations, demonstrating excellent sensitivity and selectivity, exemplified by a detection sensitivity of 10fM in the presence of a 100,000-fold excess of a non-target protein. Nanowire titration curves gave antibody-antigen dissociation constants in good agreement with low-salt enzyme-linked immunosorbent assays (ELISAs). This fabrication process produces high-quality nanowires that are suitable for lowcost mass production, providing a realistic route to the realization of disposable nanoelectronic Point-of-Care (PoC) devices.

Item Type: Article
ISSNs: 1530-6984 (print)
1530-6992 (electronic)
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Q Science > QR Microbiology > QR180 Immunology
T Technology > TP Chemical technology
Divisions: Faculty of Medicine > Infection, Inflammation and Immunity
Faculty of Natural and Environmental Sciences > Chemistry > Chemical Biology Group
Faculty of Physical Sciences and Engineering > Electronics and Computer Science > NANO
ePrint ID: 336302
Date Deposited: 21 Mar 2012 13:33
Last Modified: 27 Mar 2014 20:19
Research Funder: EPSRC
Projects:
Silicon Nanowire Arrays for Viral Infection Markers
Funded by: EPSRC (EP/G061696/1)
Led by: Peter Ashburn
1 May 2009 to 31 October 2012
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/336302

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