Squaramides as potent transmembrane anion transporters

Busschaert, Nathalie, Kirby, Isabelle L., Young, Sarah, Coles, Simon J., Horton, Peter N., Light, Mark E. and Gale, Philip A. (2012) Squaramides as potent transmembrane anion transporters. Angewandte Chemie International Edition, 51, (18), 4426-4430. (doi:10.1002/anie.201200729).


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Square peg in a round ball: squaramides are shown to be potent transmembrane anion transporters for both chloride and bicarbonate, performing better than the thiourea and urea analogues. Studies into the nature of this transport point to a mobile carrier mechanism, where the squaramide delivers the anion cargo across the lipid bilayer (see scheme, green sphere=anion). These drug-like molecules provide a platform for the development of a new generation of anion-transport systems.

Item Type: Article
ISSNs: 1433-7851 (print)
1521-3773 (electronic)
Keywords: anion transport, anions, fluorinated ligands, squaramides, supramolecular chemistry
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Natural and Environmental Sciences > Chemistry > Molecular Assembly, Function & Structure
ePrint ID: 336576
Date Deposited: 30 Mar 2012 11:55
Last Modified: 18 Feb 2015 10:18
URI: http://eprints.soton.ac.uk/id/eprint/336576

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