Squaramides as potent transmembrane anion transporters

Busschaert, Nathalie, Kirby, Isabelle L., Young, Sarah, Coles, Simon J., Horton, Peter N., Light, Mark E. and Gale, Philip A. (2012) Squaramides as potent transmembrane anion transporters. Angewandte Chemie International Edition, 51, (18), 4426-4430. (doi:10.1002/anie.201200729).


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Square peg in a round ball: squaramides are shown to be potent transmembrane anion transporters for both chloride and bicarbonate, performing better than the thiourea and urea analogues. Studies into the nature of this transport point to a mobile carrier mechanism, where the squaramide delivers the anion cargo across the lipid bilayer (see scheme, green sphere=anion). These drug-like molecules provide a platform for the development of a new generation of anion-transport systems.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1002/anie.201200729
ISSNs: 1433-7851 (print)
1521-3773 (electronic)
Keywords: anion transport, anions, fluorinated ligands, squaramides, supramolecular chemistry
Subjects: Q Science > QD Chemistry
Divisions : Faculty of Natural and Environmental Sciences > Chemistry > Organic Chemistry: Synthesis, Catalysis and Flow
ePrint ID: 336576
Accepted Date and Publication Date:
27 March 2012Published
Date Deposited: 30 Mar 2012 11:55
Last Modified: 31 Mar 2016 14:25
URI: http://eprints.soton.ac.uk/id/eprint/336576

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