Squaramides as potent transmembrane anion transporters
Busschaert, Nathalie, Kirby, Isabelle L., Young, Sarah, Coles, Simon J., Horton, Peter N., Light, Mark E. and Gale, Philip A. (2012) Squaramides as potent transmembrane anion transporters. Angewandte Chemie International Edition, 51, 4426-4430. (doi:10.1002/anie.201200729).
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Description/Abstract
Square peg in a round ball: squaramides are shown to be potent transmembrane anion transporters for both chloride and bicarbonate, performing better than the thiourea and urea analogues. Studies into the nature of this transport point to a mobile carrier mechanism, where the squaramide delivers the anion cargo across the lipid bilayer (see scheme, green sphere=anion). These drug-like molecules provide a platform for the development of a new generation of anion-transport systems.
| Item Type: | Article |
|---|---|
| ISSNs: | 1433-7851 (print) 1521-3773 (electronic) |
| Keywords: | anion transport, anions, fluorinated ligands, squaramides, supramolecular chemistry |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Natural and Environmental Sciences > Chemistry > Molecular Assembly, Function & Structure |
| Item ID: | 336576 |
| Date Deposited: | 30 Mar 2012 11:55 |
| Last Modified: | 26 Aug 2012 00:08 |
| Contributors: | Busschaert, Nathalie (Author) Kirby, Isabelle L. (Author) Young, Sarah (Author) Coles, Simon J. (Author) Horton, Peter N. (Author) Light, Mark E. (Author) Gale, Philip A. (Author) |
| Date: | 27 March 2012 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/336576 |
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