Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones
Jones, Raymond C F, Choudhury, Abdul K, Iley, James N, Light, Mark E, Loizou, Georgia and Pillainayagam, Terence A (2012) Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones. Beilstein Journal of Organic Chemistry, 8, 308-312. (doi:10.3762/bjoc.8.33).
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Description/Abstract
A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone natural products
| Item Type: | Article |
|---|---|
| ISSNs: | 1860-5397 (print) 1860-5397 (electronic) |
| Keywords: | aldol reaction, fused-ring systems, heterocycles, isoxazole, metalation, pyridone |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Natural and Environmental Sciences > Chemistry |
| Item ID: | 336655 |
| Date Deposited: | 02 Apr 2012 15:07 |
| Last Modified: | 02 Apr 2012 15:07 |
| Contributors: | Jones, Raymond C F (Author) Choudhury, Abdul K (Author) Iley, James N (Author) Light, Mark E (Author) Loizou, Georgia (Author) Pillainayagam, Terence A (Author) |
| Date: | 27 February 2012 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/336655 |
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