Programmable one-pot multistep organic synthesis using DNA junctions

McKee, Mireya L., Milnes, Phillip J., Bath, Jonathan, Stulz, Eugen, O’Reilly, Rachel K. and Turberfield, Andrew J. (2012) Programmable one-pot multistep organic synthesis using DNA junctions. Journal of the American Chemical Society, 134, (3), 1446-1449. (doi:10.1021/ja2101196).


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A system for multistep DNA-templated synthesis is controlled by the sequential formation of DNA junctions. Reactants are attached to DNA adapters which are brought together by hybridization to DNA template strands. This process can be repeated to allow sequence-controlled oligomer synthesis while maintaining a constant reaction environment, independent of oligomer length, at each reaction step. Synthesis can take place in a single pot containing all required reactive monomers. Different oligomers can be synthesized in parallel in the same vessel, and the products of parallel synthesis can be ligated, reducing the number of reaction steps required to produce an oligomer of a given length

Item Type: Article
Digital Object Identifier (DOI): doi:10.1021/ja2101196
ISSNs: 0002-7863 (print)
1520-5126 (electronic)
Subjects: Q Science > QD Chemistry
Divisions : ?? uos2011-F6-EB-MD ??
ePrint ID: 336788
Accepted Date and Publication Date:
January 2012Published
Date Deposited: 11 Apr 2012 10:04
Last Modified: 31 Mar 2016 14:25
Molecular materials, sensors and circuits with nanometre resolution
Funded by: EPSRC (EP/I016651/1)
Led by: Eugen Stulz
1 November 2010 to 30 April 2012
Molecular Software and Hardware for Programmed Chemical Synthesis
Funded by: EPSRC (EP/F056826/1)
Led by: Eugen Stulz
15 October 2008 to 14 April 2012
Software-controlled assembly of oligomers
Funded by: EPSRC (EP/F009186/1)
Led by: Eugen Stulz
1 October 2007 to 31 January 2011

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