Macrocylic bisbibenzyl natural products and their chemical synthesis

Harrowven, David C. and Kostiuk, Sarah L. (2012) Macrocylic bisbibenzyl natural products and their chemical synthesis. Natural Product Reports, 29, (2), 223-242. (doi:10.1039/c1np00080b). (PMID:22089169).


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The macrocyclic bisbibenzyl family of natural products are commonly found in liverworts and other bryophytes, though the recent isolation of riccardin C from a primrose extract has demonstrated their existence in higher flowering plants. Each has a core comprising four aromatic rings and two ethano-bridges, being derived in Nature from two molecules of lunularin. Sub-classes are distinguished by the connectivity between these lunularin units, while individual natural products are distinguished by the hydroxy- and/or alkoxy-substituents decorating the core structures. Further diversification results
from halogenation and oxidation, which may lead to dimerization or the creation of additional rings.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1039/c1np00080b
ISSNs: 0265-0568 (print)
1460-4752 (electronic)
Keywords: natural products, halogenation, oxidation, dimerization, DNA
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH426 Genetics
Divisions : Faculty of Natural and Environmental Sciences > Chemistry > Organic Chemistry: Synthesis, Catalysis and Flow
ePrint ID: 337216
Accepted Date and Publication Date:
February 2012Published
16 November 2011Made publicly available
Date Deposited: 20 Apr 2012 10:25
Last Modified: 31 Mar 2016 14:26

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