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Too much of a good thing: management of BCG vaccine overdose

Too much of a good thing: management of BCG vaccine overdose
Too much of a good thing: management of BCG vaccine overdose
A 14-year-old girl was inadvertently immunised with an excessively large dose of BCG-Connaught vaccine (1.0 ml instead of 0.1 ml). Examination of the patient a few hours later revealed a subcutaneous fluctuant tender lump at the injection site. This was surgically excised within 12h of immunisation and she was treated with isoniazid and rifampicin for six weeks. The patient developed no complications, other than a minor surgical scar. This case highlights the importance of the correct administration and dosing of BCG vaccine and suggests a management option that may prevent the severe local and systemic complications that are frequently associated with BCG overdose.
bcg, overdose, vaccine, immunisation, tuberculosis, medical error
5562-5564
Ritz, Nicole
ce6604a1-f373-4d76-838a-1ae75f35b20b
Tebruegge, Marc
2c3dff22-0b5f-48a7-bb36-ce323705f74a
Streeton, Jonathan
5b647b94-9862-4f31-8f28-35c7b8d5ba6d
Curtis, Nigel
60e08f70-7ce9-42b3-8074-d5df55131b12
Ritz, Nicole
ce6604a1-f373-4d76-838a-1ae75f35b20b
Tebruegge, Marc
2c3dff22-0b5f-48a7-bb36-ce323705f74a
Streeton, Jonathan
5b647b94-9862-4f31-8f28-35c7b8d5ba6d
Curtis, Nigel
60e08f70-7ce9-42b3-8074-d5df55131b12

Ritz, Nicole, Tebruegge, Marc, Streeton, Jonathan and Curtis, Nigel (2009) Too much of a good thing: management of BCG vaccine overdose. Vaccine, 27 (41), 5562-5564. (doi:10.1016/j.vaccine.2009.07.043). (PMID:19654063)

Record type: Article

Abstract

A 14-year-old girl was inadvertently immunised with an excessively large dose of BCG-Connaught vaccine (1.0 ml instead of 0.1 ml). Examination of the patient a few hours later revealed a subcutaneous fluctuant tender lump at the injection site. This was surgically excised within 12h of immunisation and she was treated with isoniazid and rifampicin for six weeks. The patient developed no complications, other than a minor surgical scar. This case highlights the importance of the correct administration and dosing of BCG vaccine and suggests a management option that may prevent the severe local and systemic complications that are frequently associated with BCG overdose.

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More information

Published date: 18 September 2009
Keywords: bcg, overdose, vaccine, immunisation, tuberculosis, medical error
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 337638
URI: http://eprints.soton.ac.uk/id/eprint/337638
DOI: doi:10.1016/j.vaccine.2009.07.043
PURE UUID: 873c4bde-a0e8-4862-bd42-4722250d138f

Catalogue record

Date deposited: 02 May 2012 08:39
Last modified: 14 Mar 2024 10:56

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Contributors

Author: Nicole Ritz
Author: Marc Tebruegge
Author: Jonathan Streeton
Author: Nigel Curtis

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