Too much of a good thing: management of BCG vaccine overdose

Ritz, Nicole, Tebruegge, Marc, Streeton, Jonathan and Curtis, Nigel (2009) Too much of a good thing: management of BCG vaccine overdose. Vaccine, 27, (41), 5562-5564. (doi:10.1016/j.vaccine.2009.07.043). (PMID:19654063).


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A 14-year-old girl was inadvertently immunised with an excessively large dose of BCG-Connaught vaccine (1.0 ml instead of 0.1 ml). Examination of the patient a few hours later revealed a subcutaneous fluctuant tender lump at the injection site. This was surgically excised within 12h of immunisation and she was treated with isoniazid and rifampicin for six weeks. The patient developed no complications, other than a minor surgical scar. This case highlights the importance of the correct administration and dosing of BCG vaccine and suggests a management option that may prevent the severe local and systemic complications that are frequently associated with BCG overdose.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.vaccine.2009.07.043
ISSNs: 0264-410X (print)
0264-410X (electronic)
Keywords: bcg, overdose, vaccine, immunisation, tuberculosis, medical error
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions : Faculty of Medicine
ePrint ID: 337638
Accepted Date and Publication Date:
18 September 2009Published
Date Deposited: 02 May 2012 08:39
Last Modified: 31 Mar 2016 14:27

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