Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: a comparative approach


Fago, Angela, Jensen, Frank B., Tota, Bruno, Feelisch, Martin, Olson, Kenneth R., Helbo, Signe, Lefevre, Sjannie, Mancardi, Daniele, Palumbo, Anna, Sandvik, Guro K. and Skovgaard, Nini (2012) Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: a comparative approach. Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology, 162, (1), 1-6. (doi:10.1016/j.cbpa.2012.01.011). (PMID:22314020).

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Description/Abstract

Hydrogen sulfide (H(2)S), nitric oxide (NO) and nitrite (NO(2)(-)) are formed in vivo and are of crucial importance in the tissue response to hypoxia, particularly in the cardiovascular system, where these signaling molecules are involved in a multitude of processes including the regulation of vascular tone, cellular metabolic function and cytoprotection. This report summarizes current advances on the mechanisms by which these signaling pathways act and may have evolved in animals with different tolerance to hypoxia, as presented and discussed during the scientific sessions of the annual meeting of the Society for Experimental Biology in 2011 in Glasgow. It also highlights the need and potential for a comparative approach of study and collaborative effort to identify potential link(s) between the signaling pathways involving NO, nitrite and H(2)S in the whole-body responses to hypoxia.

Item Type: Article
ISSNs: 1096-4959 (print)
1095-6433 (electronic)
Keywords: gasotransmitter, oxygen sensing, s-nitrosothiols, vasoconstriction, vasodilation, cytoprotection
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Faculty of Medicine > Infection, Inflammation and Immunity
ePrint ID: 337691
Date Deposited: 02 May 2012 11:22
Last Modified: 27 Mar 2014 20:21
URI: http://eprints.soton.ac.uk/id/eprint/337691

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