Nitrate and nitrite in biology, nutrition and therapeutics


Lundberg, Jon O., Gladwin, Mark T., Ahluwalia, Amrita, Benjamin, Nigel, Bryan, Nathan S., Butler, Anthony, Cabrales, Pedro, Fago, Angela, Feelisch, Martin, Ford, Peter C., Freeman, Bruce A., Frenneaux, Michael, Friedman, Joel, Kelm, Malte, Kevil, Christopher G., Kim-Shapiro, Daniel B., Kozlov, Andrey V., Lancaster Jr, Jack R., Lefer, David J., McColl, Kenneth, McCurry, Kenneth, Patel, Rakesh P., Petersson, Joel, Rassaf, Tienush, Reutov, Valentin P., Richter-Addo, George B., Schechter, Alan, Shiva, Sruti, Tsuchiya, Koichiro, van Faassen, Ernst E., Webb, Andrew J., Zuckerbraun, Brian S., Zweier, Jay L. and Weitzberg, Eddie (2009) Nitrate and nitrite in biology, nutrition and therapeutics. Nature Chemical Biology, 5, (12), 865-869. (doi:10.1038/nchembio.260). (PMID:19915529).

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Description/Abstract

Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.

Item Type: Article
ISSNs: 1552-4450 (print)
1552-4469 (electronic)
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine > Infection, Inflammation and Immunity
ePrint ID: 337700
Date Deposited: 02 May 2012 13:01
Last Modified: 27 Mar 2014 20:21
URI: http://eprints.soton.ac.uk/id/eprint/337700

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