Nitrate and nitrite in biology, nutrition and therapeutics

Lundberg, Jon O., Gladwin, Mark T., Ahluwalia, Amrita, Benjamin, Nigel, Bryan, Nathan S., Butler, Anthony, Cabrales, Pedro, Fago, Angela, Feelisch, Martin, Ford, Peter C., Freeman, Bruce A., Frenneaux, Michael, Friedman, Joel, Kelm, Malte, Kevil, Christopher G., Kim-Shapiro, Daniel B., Kozlov, Andrey V., Lancaster Jr, Jack R., Lefer, David J., McColl, Kenneth, McCurry, Kenneth, Patel, Rakesh P., Petersson, Joel, Rassaf, Tienush, Reutov, Valentin P., Richter-Addo, George B., Schechter, Alan, Shiva, Sruti, Tsuchiya, Koichiro, van Faassen, Ernst E., Webb, Andrew J., Zuckerbraun, Brian S., Zweier, Jay L. and Weitzberg, Eddie (2009) Nitrate and nitrite in biology, nutrition and therapeutics. Nature Chemical Biology, 5, (12), 865-869. (doi:10.1038/nchembio.260). (PMID:19915529).


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Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1038/nchembio.260
ISSNs: 1552-4450 (print)
1552-4469 (electronic)
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
R Medicine > RM Therapeutics. Pharmacology
Divisions : Faculty of Medicine > Clinical and Experimental Sciences
ePrint ID: 337700
Accepted Date and Publication Date:
December 2009Published
Date Deposited: 02 May 2012 13:01
Last Modified: 31 Mar 2016 14:27

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