Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma


Johnson, David C., Corthals, Sophie L., Walker, Brian A., Ross, Fiona M., Gregory, Walter M., Dickens, Nicholas J., Lokhorst, Henk M., Goldschmidt, Hartmut, Davies, Faith E., Durie, Brian G. M., Van Ness, Brian, Child, J. Anthony, Sonneveld, Pieter and Morgan, Gareth J. (2011) Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma. Journal of Clinical Oncology, 29, (7), 797-804. (doi:10.1200/JCO.2010.28.0792 ). (PMID:21245424).

Download

Full text not available from this repository.

Description/Abstract

Our results are consistent with the hypothesis that an individual's risk of developing a peripheral neuropathy after thalidomide treatment can be mediated by polymorphisms in genes governing repair mechanisms and inflammation in the peripheral nervous system. These findings will contribute to the development of future neuroprotective strategies with thalidomide therapy and the better use of this important compound.

Item Type: Article
ISSNs: 0732-183X (print)
1527-7755 (electronic)
Related URLs:
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Medicine > Human Development and Health
ePrint ID: 337735
Date Deposited: 02 May 2012 14:03
Last Modified: 27 Mar 2014 20:21
URI: http://eprints.soton.ac.uk/id/eprint/337735

Actions (login required)

View Item View Item