Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma
Johnson, David C., Corthals, Sophie L., Walker, Brian A., Ross, Fiona M., Gregory, Walter M., Dickens, Nicholas J., Lokhorst, Henk M., Goldschmidt, Hartmut, Davies, Faith E., Durie, Brian G. M., Van Ness, Brian, Child, J. Anthony, Sonneveld, Pieter and Morgan, Gareth J. (2011) Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma. Journal of Clinical Oncology, 29, (7), 797-804. (doi:10.1200/JCO.2010.28.0792 ). (PMID:21245424).
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Our results are consistent with the hypothesis that an individual's risk of developing a peripheral neuropathy after thalidomide treatment can be mediated by polymorphisms in genes governing repair mechanisms and inflammation in the peripheral nervous system. These findings will contribute to the development of future neuroprotective strategies with thalidomide therapy and the better use of this important compound.
|Subjects:||Q Science > QH Natural history > QH426 Genetics|
|Divisions:||Faculty of Medicine > Human Development and Health
|Date Deposited:||02 May 2012 14:03|
|Last Modified:||02 May 2012 14:03|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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