Cardioprotective effects of vegetables: is nitrate the answer?
Cardioprotective effects of vegetables: is nitrate the answer?
A diet rich in fruits and vegetables is associated with a lower risk of certain forms of cancer and cardiovascular disease, but the mechanisms behind this protection are not completely understood. Recent epidemiological studies suggest a cardioprotective action afforded specifically by green leafy vegetables. We here propose that these beneficial effects are related to the high content of inorganic nitrate, which in concert with symbiotic bacteria in the oral cavity is converted into nitrite, nitric oxide, and secondary reaction products with vasodilating and tissue-protective properties.
nitric oxide, nitrite, cardiovascular, nitrate reductase, hypertension, gastric cancer
359-362
Lundberg, Jon O.
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Feelisch, Martin
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Björne, Håkan
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Jansson, Emmelie
030c52f6-e199-4b4b-a909-937d6c16701d
Weitzberg, Eddie
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December 2006
Lundberg, Jon O.
8da24e54-32ab-45a9-9b53-51e5531e6a90
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Björne, Håkan
4f56f2c8-63e8-4882-a1da-cb23db8bb92a
Jansson, Emmelie
030c52f6-e199-4b4b-a909-937d6c16701d
Weitzberg, Eddie
aee1ed25-ae25-460e-b2b2-6cc146ae36cd
Lundberg, Jon O., Feelisch, Martin, Björne, Håkan, Jansson, Emmelie and Weitzberg, Eddie
(2006)
Cardioprotective effects of vegetables: is nitrate the answer?
Nitric Oxide, 15 (4), .
(doi:10.1016/j.niox.2006.01.013).
(PMID:16563818)
Abstract
A diet rich in fruits and vegetables is associated with a lower risk of certain forms of cancer and cardiovascular disease, but the mechanisms behind this protection are not completely understood. Recent epidemiological studies suggest a cardioprotective action afforded specifically by green leafy vegetables. We here propose that these beneficial effects are related to the high content of inorganic nitrate, which in concert with symbiotic bacteria in the oral cavity is converted into nitrite, nitric oxide, and secondary reaction products with vasodilating and tissue-protective properties.
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e-pub ahead of print date: 24 March 2006
Published date: December 2006
Keywords:
nitric oxide, nitrite, cardiovascular, nitrate reductase, hypertension, gastric cancer
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 337833
URI: http://eprints.soton.ac.uk/id/eprint/337833
ISSN: 1089-8603
PURE UUID: 93d82d81-bac1-448b-a3c4-ce8f948f92c7
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Date deposited: 04 May 2012 14:35
Last modified: 15 Mar 2024 03:41
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Contributors
Author:
Jon O. Lundberg
Author:
Håkan Björne
Author:
Emmelie Jansson
Author:
Eddie Weitzberg
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