Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension


Preik, Michael, Kelm, Malte, Feelisch, Martin and Strauer, Bodo E. (1996) Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension. Journal of Hypertension, 14, (7), 903-908. (PMID:8818930).

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Description/Abstract

Dilation of resistance arteries in response to infusion of nitric oxide donors is impaired in hypertensive patients and the degree of this impairment depends critically on the severity of arterial hypertension. The reduced effectiveness of nitric oxide appears to be independent of the class of nitric oxide donor and thus of the mode of intravascular nitric oxide generation. These findings are likely to have important implications not only for our understanding of the pathophysiological mechanisms of endothelial dysfunction but also for nitric oxide donor therapy in arterial hypertension.

Item Type: Article
ISSNs: 0263-6352 (print)
Related URLs:
Subjects: Q Science > QP Physiology
Q Science > QR Microbiology > QR180 Immunology
R Medicine > RC Internal medicine
Divisions: Faculty of Medicine > Infection, Inflammation and Immunity
ePrint ID: 337891
Date Deposited: 29 Jun 2012 14:07
Last Modified: 27 Mar 2014 20:21
URI: http://eprints.soton.ac.uk/id/eprint/337891

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