The early role of nitric oxide in evolution

Feelisch, Martin and Martin, John F. (1995) The early role of nitric oxide in evolution. Trends in Ecology & Evolution, 10, (12), 496-499. (doi:10.1016/S0169-5347(00)89206-X). (PMID:21237124).


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Nitric oxide (NO), which today serves many different purposes in regulating complex cellular functions, must have played a crucial role in the early stages of the evolution of life. The formation of NO may have been a critical defence mechanism for primitive microorganisms at a time when life faced the problem of rising atmospheric levels of ozone (03) formed upon photolysis of oxygen (Oz), which occurred shortly after the development of respiration in cyanobacteria. The production of NO by organisms would have allowed neutralization of toxic 03 by chemical reaction outside the cell, thus acting as a protective mechanism against oxidative destruction, allowing evolutionary advantage. Later, NO production might have allowed the control of reactive OZ species within cells before the development of specific electron-accepting enzymes. The pathway of NO formation was then consequently developed further to serve other useful functions. Although mammalian cells produce NO from L-arginine, the origin of this ability might have arisen from the essential process of either nitrification or denitrification in prokaryotic cells.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/S0169-5347(00)89206-X
ISSNs: 0169-5347 (print)
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Q Science > QP Physiology
Divisions : Faculty of Medicine > Clinical and Experimental Sciences
ePrint ID: 337893
Accepted Date and Publication Date:
December 1995Published
Date Deposited: 29 Jun 2012 14:16
Last Modified: 31 Mar 2016 14:27

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