Nitric oxide (NO) formation from nitrovasodilators occurs independently of hemoglobin or non-heme iron


Feelisch, Martin and Noack, Eike (1987) Nitric oxide (NO) formation from nitrovasodilators occurs independently of hemoglobin or non-heme iron. European Journal of Pharmacology, 142, (3), 465-469. (doi:10.1016/0014-2999(87)90090-2). (PMID:3123257).

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Description/Abstract

The aim of the present study was to exclude a potential role of hemoglobin in the formation of nitric oxide (NO) from several nitrovasodilators. NO was measured with a chemiluminescence technique after purging with argon from the aqueous solution. Nitric oxide generation occurred in the absence of hemoglobin or non-heme iron. Sodium nitroprusside and SIN-1 released NO spontaneously. Nitroglycerin produced NO only in the presence of those thiols which are effective co-stimulators of guanylate cyclase. All other thiols degraded nitroglycerin only into nitrite ions without formation of NO. Our results support the role of nitric oxide as terminal activator of guanylate cyclase stimulation by nitrovasodilators.

Item Type: Article
ISSNs: 0014-2999 (print)
Keywords: nitroglycerin, nitric oxide, thiols, nitrite, hemoglobin, guanylate cyclase, edrf (endothelium-derived relaxing factor)
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine > Infection, Inflammation and Immunity
ePrint ID: 337927
Date Deposited: 14 Jun 2012 15:09
Last Modified: 27 Mar 2014 20:21
URI: http://eprints.soton.ac.uk/id/eprint/337927

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